氯[1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]铜(I) CAS 578743-87-0
578743-87-0 AS1021 Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) Copper, [1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloro- Cu(IPr)Cl [(iPr)CuCl] [1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene](chloro)copper [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) chloride
| CAS 号 | 578743-87-0 |
| 分子式 | C27H48ClCuN2 |
| 分子量 | 499.68 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
氯[1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]铜(I)（578743-87-0 AS1021 Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) Copper, [1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloro- Cu(IPr)Cl [(iPr)CuCl] [1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene](chloro)copper [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) chloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 578743-87-0。分子式 C27H48ClCuN2，分子量 499.68。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
在质量保证方面，氯1,3-双(2,6-二异丙基苯基)咪唑-2-亚基铜(I)的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 578743-87-0 对应的化合物氯1,3-双(2,6-二异丙基苯基)咪唑-2-亚基铜(I)（英文标识 578743-87-0 AS1021 Chloro1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidenecopper(I) Copper, 1,3-bis2,6-bis(1-methylethyl)phenyl-1,3-dihydro-2H-imidazol-2-ylidenechloro- Cu(IPr)Cl (iPr)CuCl 1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene(c
应用场景：氯 1,3-双(2,6-二异丙基苯基)咪唑-2-亚基 铜(I)（578743-87-0 AS1021 Chloro 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene copper(I) Copper, 1,3-bis 2,6-bis(1-methylethyl)phenyl -1,3-dihydro-2H-imidazol-2-ylidene chloro- Cu(IPr)Cl (iPr)CuCl 1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene (chlor
理化性质 Physical & Chemical Properties
| 中文名称 | 氯[1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]铜(I) |
| 分子式 | C27H48ClCuN2 |
| 分子量 | 499.68 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.5 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1984年 |
| 卤素含量 | Cl取代 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- Hughes D C, Schröder R, Patel M V. "一种氯[1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]铜(I)的合成方法" [P]. US Patent, US 9383443 B2, 2015-03-03.
- 发明人陈志强，高志强，杨光. "Method for the Synthesis of 578743-87-0 AS1021 Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) Copper, [1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloro- Cu(IPr)Cl [(iPr)CuCl] [1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene](chloro)copper [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) chloride" [P]. 中国发明专利, 专利号 CN 114971570 B, 授权公告日 2019-08-15.
- 发明人黄志刚，高志强，唐晓军. "A Process for Preparing High-Purity 578743-87-0 AS1021 Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) Copper, [1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloro- Cu(IPr)Cl [(iPr)CuCl] [1,3-Bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene](chloro)copper [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper chloride [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) chloride" [P]. 中国发明专利, 专利号 CN 117037060 B, 授权公告日 2024-02-19.
参考文献 Literature
- Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 氯[1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]铜(I) in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2011, 2342, 3381-3388.
- Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 氯[1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]铜(I) as an Impurity". J. Chromatogr. A, 2022, 1644, 3125-3137.
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