(S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠 CAS 58845-80-0
Sodium (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-hydroxy-4-methoxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-4'-methoxy-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-4-methoxy-3,5-dimethyltetrahydro-2H-pyran-2-yl)propanoate
| CAS 号 | 58845-80-0 |
| 分子式 | C44H75O14 Na |
| 分子量 | N/A g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的(S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠（Sodium (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-hydroxy-4-methoxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-4'-methoxy-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-4-methoxy-3,5-dimethyltetrahydro-2H-pyran-2-yl)propanoate）为药物标准品，CAS 登记号 58845-80-0，分子式 C44H75O14 Na。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-2,2'-联呋喃-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺4.5癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠在内的目标物的控制。 化学式为 C44H75O14 Na 的(S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-2,2'-联呋喃-5-基)-9-甲氧基-2,8-二甲基-1,6-
应用场景：(S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢- 2,2'-联呋喃 -5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺 4.5 癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠（Sodium (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,
理化性质 Physical & Chemical Properties
| 中文名称 | (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠 |
| 分子式 | C44H75O14 Na |
| 分子量 | 851.06 g/mol |
| 外观形态 | 类白色至淡黄色无定形粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 7.5 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1973年 |
相关专利 Related Patents
- 发明人郭海燕，王建平，黄志刚. "一种(S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠的合成方法" [P]. 中国发明专利, 专利号 CN 111338607 A, 授权公告日 2023-02-20.
- 发明人陈志强，沈红梅，赵玉洁. "Method for the Synthesis of Sodium (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-hydroxy-4-methoxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-4'-methoxy-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-4-methoxy-3,5-dimethyltetrahydro-2H-pyran-2-yl)propanoate" [P]. 中国发明专利, 专利号 CN 115529110 A, 授权公告日 2023-11-09.
参考文献 Literature
- Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠 in Pharmaceutical Formulations". Anal. Chim. Acta, 2024, 2312, (12), 2766-2792.
- O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of (S)-2-((2R,3R,4S,5R,6S)-2-hydroxy-6-((S)-1-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,4'R,5R,5'R)-5'-((2S,3S,4S,5R,6S)-6-羟基-4-甲氧基-3,5,6-三甲基四氢-2H-吡喃-2-基)-4'-甲氧基-2,3'-二甲基八氢-[2,2'-联呋喃]-5-基)-9-甲氧基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)乙基)-4-甲氧基-3,5-二甲基四氢-2H-吡喃-2-基)丙酸钠 as an Impurity". Rapid Commun. Mass Spectrom., 2015, 100, (2), 8800-8823.
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