邻甲酚酞 CAS 596-27-0

596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G

纯度 97%+现货药物标准品
CAS 号596-27-0
分子式C22H36O4
分子量364.52 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

邻甲酚酞 596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G CAS 596-27-0 结构式 Chemical Structure

产品介绍 Description

邻甲酚酞（英文名 596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G，CAS 596-27-0）属于药物标准品。分子式 C22H36O4，分子量 364.52。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

邻甲酚酞（596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G），CAS注册编号 596-27-0，化学分子式为 C22H36O4，分子量 364.52 g/mol。 邻甲酚酞（分子式 C22H36O4）的化学结构中包含甾体骨架，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。由于碳链较长，脂溶性良好，该化合物在Octanol-Water分配系

应用场景：邻甲酚酞（596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XO

理化性质 Physical & Chemical Properties

中文名称邻甲酚酞
分子式C22H36O4
分子量364.52 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人唐晓军，王建平，黄志刚. "一种邻甲酚酞的合成方法" [P]. 中国发明专利, 专利号 CN 114944436 A, 授权公告日 2025-02-07.
  2. 发明人林芳，陈志强，黄志刚. "Method for the Synthesis of 596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G" [P]. 中国发明专利, 专利号 CN 111897861 A, 授权公告日 2017-06-20.
  3. Roberts E F, Kumar R, Williams B T. "A Process for Preparing High-Purity 596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G" [P]. US Patent, US 10837230 B2, 2018-01-17.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 邻甲酚酞 in Pharmaceutical Formulations". Chemosphere, 2021, 2109, 2528-2558.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 邻甲酚酞 as an Impurity". Anal. Methods, 2023, 1085, (5), 2985-2989.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 596-27-0 XOU2D9049G Cresolphthalein o-Cresolphthalein 3,3-Bis(4-hydroxy-m-tolyl)phthalide 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- Phenolphthalein, 3',3''-dimethyl- 5-18-04-00193 (Beilstein Handbook Reference) BRN 0310554 3',3''-Dimethylphenolphthalein EINECS 209-881-8 UNII-XOU2D9049G Using HRMS and NMR". Molecules, 2014, 1783, 1870-1878.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 邻甲酚酞 Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2013, 1073, 5943-5956.

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