CAS 599179-03-0

599179-03-0 EP3QG127N9 Vicriviroc maleate [USAN] Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)-but-2-enedioate UNII-EP3QG127N9

纯度 97%+现货药物标准品
CAS 号599179-03-0
分子式C28H38F3N5O2 C4H4O4
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

599179-03-0 EP3QG127N9 Vicriviroc maleate [USAN] Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)-but-2-enedioate UNII-EP3QG127N9 CAS 599179-03-0 结构式 Chemical Structure

产品介绍 Description

（599179-03-0 EP3QG127N9 Vicriviroc maleate [USAN] Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)-but-2-enedioate UNII-EP3QG127N9，CAS 号 599179-03-0）是 CATO 佳途自主生产的药物标准品，分子式 C28H38F3N5O2 C4H4O4。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，的分子量为649.71 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 599179-03-0 对应的化合物（英文标识 599179-03-0 EP3QG127N9 Vicriviroc maleate USAN Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)

应用场景：在化学分析实验室中，（CAS 599179-03-0）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C28H38F3N5O2 C4H4O4
分子量649.71 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）13.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
卤素含量F取代
含氮原子数5

相关专利 Related Patents

  1. 发明人郑宇鹏，徐明华，韩伟. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 110976842 A, 授权公告日 2018-09-01.
  2. 发明人朱建伟，王建平，胡光. "Method for the Synthesis of 599179-03-0 EP3QG127N9 Vicriviroc maleate [USAN] Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)-but-2-enedioate UNII-EP3QG127N9" [P]. 中国发明专利, 专利号 CN 112593768 B, 授权公告日 2022-06-15.
  3. 发明人胡光，韩伟，杨光. "A Process for Preparing High-Purity 599179-03-0 EP3QG127N9 Vicriviroc maleate [USAN] Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)-but-2-enedioate UNII-EP3QG127N9" [P]. 中国发明专利, 专利号 CN 112274721 B, 授权公告日 2021-10-28.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chem., 2018, 588, 6833-6849.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Molecules, 2012, 1802, (2), 5688-5712.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 599179-03-0 EP3QG127N9 Vicriviroc maleate [USAN] Piperidine, 1-((4,6-dimethyl-5-pyrididinyl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methyl-1-piperazinyl)-4-methyl-, (2Z)-2-butenedioate (2:1) Vicriviroc maleate SCH 417690 SCH-D 1-((4,6-Dimethylpyrimidin-5-yl)carbonyl)-4-((3S)-4-((1R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidine (2Z)-but-2-enedioate UNII-EP3QG127N9 Using HRMS and NMR". Anal. Chim. Acta, 2012, 463, (11), 7504-7528.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2022, 1197, 2585-2604.

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