(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯 CAS 64421-27-8

(1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate

纯度 97%+现货药物标准品
CAS 号64421-27-8
分子式C17H26O10
分子量390.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯 (1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate CAS 64421-27-8 结构式 Chemical Structure

产品介绍 Description

CAS 64421-27-8 对应的(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯（(1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C17H26O10，分子量 390.38。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并c吡喃-4-羧酸甲酯的产生途径与其化学式中羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 64421-27-8 对应的化合物(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并c吡喃-4-羧酸甲酯（英文标识 (1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopentacpyran-4-carboxylate），化学式

应用场景：(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并 c 吡喃-4-羧酸甲酯（(1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta c pyran-4-carboxylate，CAS

理化性质 Physical & Chemical Properties

中文名称(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯
分子式C17H26O10
分子量390.38 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1975年

相关专利 Related Patents

  1. 发明人郭海燕，杨光，马晓峰. "一种(1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 111072482 A, 授权公告日 2015-11-15.
  2. 发明人冯建国，周伟，李文辉. "Method for the Synthesis of (1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate" [P]. 中国发明专利, 专利号 CN 113710537 A, 授权公告日 2019-06-22.
  3. 发明人罗永刚，林芳，张德明. "A Process for Preparing High-Purity (1S,4aS,7S,7aS)-Methyl 7-hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate" [P]. 中国发明专利, 专利号 CN 110933567 A, 授权公告日 2019-07-04.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of (1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2015, 934, (12), 7020-7048.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1S,4aS,7S,7aS)-7-羟基-7-甲基-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,4a,5,6,7,7a-六氢环戊并[c]吡喃-4-羧酸甲酯 as an Impurity". Chemosphere, 2021, 1373, (7), 3538-3565.

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