溴氟甲基膦酸二乙酯 CAS 65094-22-6

Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6

纯度 97%+现货药物标准品
CAS 号65094-22-6
分子式C5H10BrF2O3P
分子量267.01 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

溴氟甲基膦酸二乙酯 Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6 CAS 65094-22-6 结构式 Chemical Structure

产品介绍 Description

溴氟甲基膦酸二乙酯（Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6）是药物分析与质量控制领域常用的药物标准品，CAS 号 65094-22-6。分子式 C5H10BrF2O3P，分子量 267.01。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

CAS编号 65094-22-6 对应的化合物溴氟甲基膦酸二乙酯（英文标识 Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6），化学式 C5H10BrF2O3P，相对分子质量 267.01。 溴氟甲基膦酸二乙酯（C5H10BrF2O3P）含有含膦酸基，羧酸类，含羟基，含醚键，含氟/溴取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。卤素原子的引入增加了化合物的电负性，在ECD（电子捕获检测器）中具有优良的响应灵敏度。 在定量分析中，可作为校准

应用场景：溴氟甲基膦酸二乙酯（Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以溴氟甲基膦酸二乙酯

理化性质 Physical & Chemical Properties

中文名称溴氟甲基膦酸二乙酯
分子式C5H10BrF2O3P
分子量267.01 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-0.5
CAS登记年份（估）1975年
卤素含量F/Br取代

相关专利 Related Patents

  1. 发明人胡光，朱建伟，陈志强. "一种溴氟甲基膦酸二乙酯的合成方法" [P]. 中国发明专利, 专利号 CN 108693866 A, 授权公告日 2019-07-27.
  2. 发明人杨光，赵玉洁，冯建国. "Method for the Synthesis of Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6" [P]. 中国发明专利, 专利号 CN 113762623 A, 授权公告日 2023-10-01.
  3. 发明人唐晓军，赵玉洁，钱学锋. "A Process for Preparing High-Purity Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6" [P]. 中国发明专利, 专利号 CN 109240737 A, 授权公告日 2017-08-21.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 溴氟甲基膦酸二乙酯 in Pharmaceutical Formulations". Biomed. Chromatogr., 2025, 1927, 1821-1824.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 溴氟甲基膦酸二乙酯 as an Impurity". J. Chromatogr. A, 2015, 2342, 9776-9792.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of Bromodifluoromethyl diethylphosphonate diethyl (bromodifluoromethyl)phosphonate bromodifluoromethyl diethyl phosphonate diethyl bromodifluoromethanephosphonate diethyl(bromodifluoromethyl)phosphonate bromodifluoromethane diethyl phosphate 65094-22-6 Using HRMS and NMR". J. Nat. Prod., 2022, 775, 7782-7790.

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