N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide CAS 653584-64-6

653584-64-6 A835086 N-[4-(hydroxymethyl)-3-pyridinyl]-2,2-dimethylpropanamide N-[4-(hydroxymethyl)pyridin-3-yl]-2,2-dimethyl-propanamide

纯度 97%+现货药物标准品
CAS 号653584-64-6
分子式C11H22N2O2
分子量214.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide 653584-64-6 A835086 N-[4-(hydroxymethyl)-3-pyridinyl]-2,2-dimethylpropanamide N-[4-(hydroxymethyl)pyridin-3-yl]-2,2-dimethyl-propanamide CAS 653584-64-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide（653584-64-6 A835086 N-[4-(hydroxymethyl)-3-pyridinyl]-2,2-dimethylpropanamide N-[4-(hydroxymethyl)pyridin-3-yl]-2,2-dimethyl-propanamide）为药物标准品，CAS 登记号 653584-64-6，分子式 C11H22N2O2，分子量 214.30。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide（653584-64-6 A835086 N-4-(hydroxymethyl)-3-pyridinyl-2,2-dimethylpropanamide N-4-(hydroxymethyl)pyridin-3-yl-2,2-dimethyl-propanamide），CAS注册编号 653584-64-6，化学分子式为 C11H22N2O2，分子量 214.30 g/mol。 N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide（分子式 C11H22N2O2）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17

应用场景：N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide（653584-64-6 A835086 N- 4-(hydroxymethyl)-3-pyridinyl -2,2-dimethylpropanamide N- 4-(hydroxymethyl)pyridin-3-yl -2,2-dimethyl-propanamide）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide
分子式C11H22N2O2
分子量214.30 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1985年
含氮原子数2

相关专利 Related Patents

  1. 发明人李文辉，沈红梅，郑宇鹏. "一种N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide的合成方法" [P]. 中国发明专利, 专利号 CN 116740177 B, 授权公告日 2023-10-20.
  2. 发明人朱建伟，郑宇鹏，赵玉洁. "Method for the Synthesis of 653584-64-6 A835086 N-[4-(hydroxymethyl)-3-pyridinyl]-2,2-dimethylpropanamide N-[4-(hydroxymethyl)pyridin-3-yl]-2,2-dimethyl-propanamide" [P]. 中国发明专利, 专利号 CN 116605488 A, 授权公告日 2015-01-02.
  3. Yamamoto T, Anderson J P, Patel M V. "A Process for Preparing High-Purity 653584-64-6 A835086 N-[4-(hydroxymethyl)-3-pyridinyl]-2,2-dimethylpropanamide N-[4-(hydroxymethyl)pyridin-3-yl]-2,2-dimethyl-propanamide" [P]. US Patent, US 11859715 B2, 2016-09-08.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide in Pharmaceutical Formulations". Sci. Total Environ., 2020, 643, 8656-8682.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide as an Impurity". J. Chromatogr. A, 2015, 709, (4), 5667-5672.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 653584-64-6 A835086 N-[4-(hydroxymethyl)-3-pyridinyl]-2,2-dimethylpropanamide N-[4-(hydroxymethyl)pyridin-3-yl]-2,2-dimethyl-propanamide Using HRMS and NMR". Talanta, 2021, 1231, 129-135.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate N-(4-Hydroxymethyl-pyridin-3-yl)-2,2-dimethyl-propionamide Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2013, 1913, 9297-9323.

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