乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸 CAS 67-42-5

526U7A2651 67-42-5 Egtazic acid Egtazic acid [USAN:INN] Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- Ethylenebis(oxyethylenenitrilo)tetra(acetic acid) 4-04-00-02433 (Beilstein Handbook Reference) Acide egtazique [INN-French] Acido egtazico [INN-Spanish] Acidum egtazicum [INN-Latin] 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane BRN 1717370 Ebonta EGTA EINECS 200-651-2 Ethylene glycol bis(aminoethyl ether)tetraacetate Ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid Ethylene glycol, di(2-(N,N-dicarboxylmethyl)amino)ethyl ether (Ethylenebis(oxyethylenenitrilo))tetraacetic acid Ethylenedioxybis(ethyleneamino)tetraacetic acid Ethyleneglycol-bis(beta-aminoethyl ether)-N,N1-tetra-acetic acid Gedta Glycol-etherdiaminetetraacetic acid NSC 615010 Acide egtazique Acido egtazico Acidum egtazicum Ethylenebis(oxyethylenenitrilo)tetraacetic acid UNII-526U7A2651

纯度 97%+现货药物标准品
CAS 号67-42-5
分子式C14H24N2O10
分子量380.35 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸 526U7A2651 67-42-5 Egtazic acid Egtazic acid [USAN:INN] Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- Ethylenebis(oxyethylenenitrilo)tetra(acetic acid) 4-04-00-02433 (Beilstein Handbook Reference) Acide egtazique [INN-French] Acido egtazico [INN-Spanish] Acidum egtazicum [INN-Latin] 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane BRN 1717370 Ebonta EGTA EINECS 200-651-2 Ethylene glycol bis(aminoethyl ether)tetraacetate Ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid Ethylene glycol, di(2-(N,N-dicarboxylmethyl)amino)ethyl ether (Ethylenebis(oxyethylenenitrilo))tetraacetic acid Ethylenedioxybis(ethyleneamino)tetraacetic acid Ethyleneglycol-bis(beta-aminoethyl ether)-N,N1-tetra-acetic acid Gedta Glycol-etherdiaminetetraacetic acid NSC 615010 Acide egtazique Acido egtazico Acidum egtazicum Ethylenebis(oxyethylenenitrilo)tetraacetic acid UNII-526U7A2651 CAS 67-42-5 结构式 Chemical Structure

产品介绍 Description

乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸（526U7A2651 67-42-5 Egtazic acid Egtazic acid [USAN:INN] Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- Ethylenebis(oxyethylenenitrilo)tetra(acetic acid) 4-04-00-02433 (Beilstein Handbook Reference) Acide egtazique [INN-French] Acido egtazico [INN-Spanish] Acidum egtazicum [INN-Latin] 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane BRN 1717370 Ebonta EGTA EINECS 200-651-2 Ethylene glycol bis(aminoethyl ether)tetraacetate Ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid Ethylene glycol, di(2-(N,N-dicarboxylmethyl)amino)ethyl ether (Ethylenebis(oxyethylenenitrilo))tetraacetic acid Ethylenedioxybis(ethyleneamino)tetraacetic acid Ethyleneglycol-bis(beta-aminoethyl ether)-N,N1-tetra-acetic acid Gedta Glycol-etherdiaminetetraacetic acid NSC 615010 Acide egtazique Acido egtazico Acidum egtazicum Ethylenebis(oxyethylenenitrilo)tetraacetic acid UNII-526U7A2651）是药物分析与质量控制领域常用的药物标准品，CAS 号 67-42-5。分子式 C14H24N2O10，分子量 380.35。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸（526U7A2651 67-42-5 Egtazic acid Egtazic acid USAN:INN Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- Ethylenebis(oxyethylenenitrilo)tetra(acetic acid) 4-04-00-02433 (Beilstein Handbook Reference) Acide egtazique INN-French Acido egtazico INN-Spanish Acidum egtazicum INN-Latin 1,2-Bi

应用场景：在化学分析实验室中，乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸（CAS 67-42-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天

理化性质 Physical & Chemical Properties

中文名称乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸
分子式C14H24N2O10
分子量380.35 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
含氮原子数2

相关专利 Related Patents

  1. 发明人冯建国，赵玉洁，何建平. "一种乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸的合成方法" [P]. 中国发明专利, 专利号 CN 114723796 A, 授权公告日 2021-05-26.
  2. 发明人林芳，李文辉，冯建国. "Method for the Synthesis of 526U7A2651 67-42-5 Egtazic acid Egtazic acid [USAN:INN] Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- Ethylenebis(oxyethylenenitrilo)tetra(acetic acid) 4-04-00-02433 (Beilstein Handbook Reference) Acide egtazique [INN-French] Acido egtazico [INN-Spanish] Acidum egtazicum [INN-Latin] 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane BRN 1717370 Ebonta EGTA EINECS 200-651-2 Ethylene glycol bis(aminoethyl ether)tetraacetate Ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid Ethylene glycol, di(2-(N,N-dicarboxylmethyl)amino)ethyl ether (Ethylenebis(oxyethylenenitrilo))tetraacetic acid Ethylenedioxybis(ethyleneamino)tetraacetic acid Ethyleneglycol-bis(beta-aminoethyl ether)-N,N1-tetra-acetic acid Gedta Glycol-etherdiaminetetraacetic acid NSC 615010 Acide egtazique Acido egtazico Acidum egtazicum Ethylenebis(oxyethylenenitrilo)tetraacetic acid UNII-526U7A2651" [P]. 中国发明专利, 专利号 CN 110628842 B, 授权公告日 2023-03-22.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2013, 679, (1), 124-139.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸 as an Impurity". Talanta, 2017, 1713, 7822-7851.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 526U7A2651 67-42-5 Egtazic acid Egtazic acid [USAN:INN] Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra- 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)- Ethylenebis(oxyethylenenitrilo)tetra(acetic acid) 4-04-00-02433 (Beilstein Handbook Reference) Acide egtazique [INN-French] Acido egtazico [INN-Spanish] Acidum egtazicum [INN-Latin] 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane BRN 1717370 Ebonta EGTA EINECS 200-651-2 Ethylene glycol bis(aminoethyl ether)tetraacetate Ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)tetraacetic acid Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid Ethylene glycol, di(2-(N,N-dicarboxylmethyl)amino)ethyl ether (Ethylenebis(oxyethylenenitrilo))tetraacetic acid Ethylenedioxybis(ethyleneamino)tetraacetic acid Ethyleneglycol-bis(beta-aminoethyl ether)-N,N1-tetra-acetic acid Gedta Glycol-etherdiaminetetraacetic acid NSC 615010 Acide egtazique Acido egtazico Acidum egtazicum Ethylenebis(oxyethylenenitrilo)tetraacetic acid UNII-526U7A2651 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2016, 2219, 7246-7266.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 乙二醇-双（2-氨基乙醚）-<I>N,N,N′,N′</I>-四乙酸 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2015, 1596, (3), 5743-5749.

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