12-oxahexadecanolide CAS 6707-60-4
6707-60-4 G6U2GR91JI 12-Oxahexadecanolide 1,6-Dioxacycloheptadecan-17-one 1,6-Dioxacycloheptadecan-7-one 12-Oxahexadecan-16-olide 5-19-04-00070 (Beilstein Handbook Reference) BRN 0158802 Cervolide EINECS 229-755-6 Hibiscolide 16-Hydroxy-12 oxahexadecanoic acid, omega-lactone 16-Hydroxy-12-oxahexadecanoic acid, omega-lactone NSC 34741 12-Oxa-1,16-hexadecanolide Undecanoic acid, 11-(4-hydroxybutoxy)-, omicron-lactone UNII-G6U2GR91JI
| CAS 号 | 6707-60-4 |
| 分子式 | C15H28O3 |
| 分子量 | 256.38 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
12-oxahexadecanolide（6707-60-4 G6U2GR91JI 12-Oxahexadecanolide 1,6-Dioxacycloheptadecan-17-one 1,6-Dioxacycloheptadecan-7-one 12-Oxahexadecan-16-olide 5-19-04-00070 (Beilstein Handbook Reference) BRN 0158802 Cervolide EINECS 229-755-6 Hibiscolide 16-Hydroxy-12 oxahexadecanoic acid, omega-lactone 16-Hydroxy-12-oxahexadecanoic acid, omega-lactone NSC 34741 12-Oxa-1,16-hexadecanolide Undecanoic acid, 11-(4-hydroxybutoxy)-, omicron-lactone UNII-G6U2GR91JI，CAS 号 6707-60-4）是 CATO 佳途自主生产的药物标准品，分子式 C15H28O3，分子量 256.38。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
12-oxahexadecanolide（C15H28O3）含有羧酸类，含羟基，含醚键。较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于碳链较长，脂溶性良好，该化合物在Octanol-Water分配系数测试中倾向于有机相。 12-oxahexadecanolide（6707-60-4 G6U2GR91JI 12-Oxahexadecanolide 1,6-Dioxacycloheptadecan-17-one 1,6-Dioxacycloheptadecan-7-one 12-Oxahexadecan-16-olide 5-19-04-00070 (Beilstein Handbook Reference) BRN 0158802 Cervolide EINECS 229-755-6 Hibiscolide 16-Hydroxy-12 oxahexadecanoic acid, omega-lactone 16-Hydroxy-12-oxahexadecanoic acid, omega-lactone NSC
应用场景：在化学分析实验室中，12-oxahexadecanolide（CAS 6707-60-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以12-oxahexadecanolide配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 12-oxahexadecanolide |
| 分子式 | C15H28O3 |
| 分子量 | 256.38 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 在推荐条件下性质稳定 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1958年 |
相关专利 Related Patents
- Roberts E F, Anderson J P, Stevens L M. "一种12-oxahexadecanolide的合成方法" [P]. US Patent, US 11994760 B2, 2015-12-16.
- 发明人冯建国，杨光，郑宇鹏. "Method for the Synthesis of 6707-60-4 G6U2GR91JI 12-Oxahexadecanolide 1,6-Dioxacycloheptadecan-17-one 1,6-Dioxacycloheptadecan-7-one 12-Oxahexadecan-16-olide 5-19-04-00070 (Beilstein Handbook Reference) BRN 0158802 Cervolide EINECS 229-755-6 Hibiscolide 16-Hydroxy-12 oxahexadecanoic acid, omega-lactone 16-Hydroxy-12-oxahexadecanoic acid, omega-lactone NSC 34741 12-Oxa-1,16-hexadecanolide Undecanoic acid, 11-(4-hydroxybutoxy)-, omicron-lactone UNII-G6U2GR91JI" [P]. 中国发明专利, 专利号 CN 109267204 B, 授权公告日 2018-11-05.
参考文献 Literature
- O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 12-oxahexadecanolide in Pharmaceutical Formulations". J. Sep. Sci., 2024, 132, (8), 465-478.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 12-oxahexadecanolide as an Impurity". J. Agric. Food Chem., 2011, 88, (1), 8833-8842.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 6707-60-4 G6U2GR91JI 12-Oxahexadecanolide 1,6-Dioxacycloheptadecan-17-one 1,6-Dioxacycloheptadecan-7-one 12-Oxahexadecan-16-olide 5-19-04-00070 (Beilstein Handbook Reference) BRN 0158802 Cervolide EINECS 229-755-6 Hibiscolide 16-Hydroxy-12 oxahexadecanoic acid, omega-lactone 16-Hydroxy-12-oxahexadecanoic acid, omega-lactone NSC 34741 12-Oxa-1,16-hexadecanolide Undecanoic acid, 11-(4-hydroxybutoxy)-, omicron-lactone UNII-G6U2GR91JI Using HRMS and NMR". Chemosphere, 2024, 1920, (11), 2196-2200.
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