特伯试剂 溶液 CAS 67719-69-1

67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent [MI] Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent

纯度 97%+现货药物标准品
CAS 号67719-69-1
分子式C3H8AlClTi 2*C5H5
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

特伯试剂 溶液 67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent [MI] Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent CAS 67719-69-1 结构式 Chemical Structure

产品介绍 Description

特伯试剂 溶液（67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent [MI] Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent）是药物分析与质量控制领域常用的药物标准品，CAS 号 67719-69-1。分子式 C3H8AlClTi 2*C5H5。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，特伯试剂 溶液的分子量为219.49 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 67719-69-1 对应的化合物特伯试剂 溶液（英文标识 67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent MI Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent），化学式 C3H8AlClTi 2C5H5，相对分子质量 219.49。 受分子结构中盐形式存在，含氯取代的影响，特伯试剂 溶液表现为白色

应用场景：特伯试剂 溶液（67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent MI Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylalumi

理化性质 Physical & Chemical Properties

中文名称特伯试剂 溶液
分子式C3H8AlClTi 2*C5H5
分子量219.49 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1976年
卤素含量Cl取代

相关专利 Related Patents

  1. 发明人钱学锋，刘建华，罗永刚. "一种特伯试剂 溶液的合成方法" [P]. 中国发明专利, 专利号 CN 109963912 A, 授权公告日 2017-05-25.
  2. 发明人孙丽萍，郑宇鹏，徐明华. "Method for the Synthesis of 67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent [MI] Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent" [P]. 中国发明专利, 专利号 CN 108616484 B, 授权公告日 2015-12-14.
  3. Kowalski A, Lefèvre J P, Björnsson E. "A Process for Preparing High-Purity 67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent [MI] Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent" [P]. European Patent, EP 3752181 A1, 2016-09-06.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 特伯试剂 溶液 in Pharmaceutical Formulations". Anal. Chem., 2017, 1988, (7), 2707-2727.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 特伯试剂 溶液 as an Impurity". Molecules, 2024, 1519, 8213-8217.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 67719-69-1 V040SDB67S mu-Methylene-mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)titanium UNII-V040SDB67S Tebbe reagent (mu-Chloro)(mu-methylene)bis(cyclopentadienyl)(dimethylaluminum)titanium Tebbe reagent [MI] Titanium, mu-chlorobis(eta5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-mu-methylene- Tebbe's reagent Using HRMS and NMR". Biomed. Chromatogr., 2012, 209, (3), 9537-9554.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 特伯试剂 溶液 Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2021, 1277, (5), 6857-6880.

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