3,3,3-Trifluoro-2-hydroxypropanoic acid CAS 684-07-1
(DL)-3,3,3-TRIFLUOROLACTIC ACID (R,S)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPANOIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPIONIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPANOIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 3,3,3-TRIFLUORO-DL-LACTIC ACID 3,3,3-TRIFLUOROLACTIC ACID 684-07-1 EF10074 PROPANOIC ACID, 3,3,3-TRIFLUORO-2-HYDROXY- TRIFLUOROLACTIC ACID
| CAS 号 | 684-07-1 |
| 分子式 | C3H3F3O3 |
| 分子量 | 144.05 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
3,3,3-Trifluoro-2-hydroxypropanoic acid（(DL)-3,3,3-TRIFLUOROLACTIC ACID (R,S)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPANOIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPIONIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPANOIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 3,3,3-TRIFLUORO-DL-LACTIC ACID 3,3,3-TRIFLUOROLACTIC ACID 684-07-1 EF10074 PROPANOIC ACID, 3,3,3-TRIFLUORO-2-HYDROXY- TRIFLUOROLACTIC ACID）是药物分析与质量控制领域常用的药物标准品，CAS 号 684-07-1。分子式 C3H3F3O3，分子量 144.05。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
CAS编号 684-07-1 对应的化合物3,3,3-Trifluoro-2-hydroxypropanoic acid（英文标识 (DL)-3,3,3-TRIFLUOROLACTIC ACID (R,S)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPANOIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPIONIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPANOIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 3,3,3-TRIFLUORO-DL-LACTIC ACID 3,3,3-TRIFLUOROLACTIC ACID 684-07-1 EF10074 PROPANOIC ACID, 3,3,3-TRIFLUORO-2-HYDROXY- TRIFLUOROLACTIC ACID），化学式 C3H3F3O3，相对分子质量 144.05。 3,3,3-Trifluoro-2-hydroxypr
应用场景：从实际应用出发，3,3,3-Trifluoro-2-hydroxypropanoic acid（CAS 684-07-1）在化学分析中作为关键的基准对照物质。 推荐以3,3,3-Trifluoro-2-hydroxypropanoic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放；
理化性质 Physical & Chemical Properties
| 中文名称 | 3,3,3-Trifluoro-2-hydroxypropanoic acid |
| 分子式 | C3H3F3O3 |
| 分子量 | 144.05 g/mol |
| 外观形态 | 白色至类白色液体。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO、水 |
| 稳定性 | 具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | F取代 |
相关专利 Related Patents
- 发明人郭海燕，徐明华，沈红梅. "一种3,3,3-Trifluoro-2-hydroxypropanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 111313815 A, 授权公告日 2016-03-18.
- 发明人胡光，韩伟，林芳. "Method for the Synthesis of (DL)-3,3,3-TRIFLUOROLACTIC ACID (R,S)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPANOIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPIONIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPANOIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 3,3,3-TRIFLUORO-DL-LACTIC ACID 3,3,3-TRIFLUOROLACTIC ACID 684-07-1 EF10074 PROPANOIC ACID, 3,3,3-TRIFLUORO-2-HYDROXY- TRIFLUOROLACTIC ACID" [P]. 中国发明专利, 专利号 CN 110003002 B, 授权公告日 2024-03-06.
参考文献 Literature
- Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 3,3,3-Trifluoro-2-hydroxypropanoic acid in Pharmaceutical Formulations". Talanta, 2019, 1416, 6130-6147.
- Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,3,3-Trifluoro-2-hydroxypropanoic acid as an Impurity". Environ. Sci. Technol., 2019, 2243, 6761-6785.
- Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (DL)-3,3,3-TRIFLUOROLACTIC ACID (R,S)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPANOIC ACID 2-HYDROXY-3,3,3-TRIFLUOROPROPIONIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPANOIC ACID 3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID 3,3,3-TRIFLUORO-DL-LACTIC ACID 3,3,3-TRIFLUOROLACTIC ACID 684-07-1 EF10074 PROPANOIC ACID, 3,3,3-TRIFLUORO-2-HYDROXY- TRIFLUOROLACTIC ACID Using HRMS and NMR". J. Chromatogr. A, 2023, 1213, (5), 1606-1632.
- Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 3,3,3-Trifluoro-2-hydroxypropanoic acid Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2018, 1763, 628-637.
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