14:0-16:0 PC CAS 69525-80-0
(2R)-2-(hexadecanoyloxy)-3-(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate 1-Myristoyl-2-palmitoylphosphatidylcholine 1-myristoyl-2-palmitoyl-GPC 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoylphosphatidylcholine 69525-80-0 CHEBI:75062 GPC(14:0/16:0) MPPC PC(14:0/16:0) PC(30:0) Phosphatidylcholine(14:0/16:0) Phosphatidylcholine(30:0)
| CAS 号 | 69525-80-0 |
| 分子式 | C38H76NO8P |
| 分子量 | 705.99 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 69525-80-0 对应的14:0-16:0 PC（(2R)-2-(hexadecanoyloxy)-3-(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate 1-Myristoyl-2-palmitoylphosphatidylcholine 1-myristoyl-2-palmitoyl-GPC 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoylphosphatidylcholine 69525-80-0 CHEBI:75062 GPC(14:0/16:0) MPPC PC(14:0/16:0) PC(30:0) Phosphatidylcholine(14:0/16:0) Phosphatidylcholine(30:0)）为 CATO 佳途药物标准品产品线成员。分子式 C38H76NO8P，分子量 705.99。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
CAS编号 69525-80-0 对应的化合物14:0-16:0 PC（英文标识 (2R)-2-(hexadecanoyloxy)-3-(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate 1-Myristoyl-2-palmitoylphosphatidylcholine 1-myristoyl-2-palmitoyl-GPC 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoylphosphatidylcholine 69525-80-0 CHEBI:75062 GPC(14:0/16:0) MPPC PC(14:0/16:0) PC(30:0) Phosphatidylcholine(14:0/16:0)
应用场景：从实际应用出发，14:0-16:0 PC（CAS 69525-80-0）在化学分析中作为关键的基准对照物质。 推荐以14:0-16:0 PC配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于室温保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 14:0-16:0 PC |
| 分子式 | C38H76NO8P |
| 分子量 | 705.99 g/mol |
| 外观形态 | 白色至类白色无定形粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.5 |
| CAS登记年份（估） | 1976年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- Lee S K, O'Brien P Q, Anderson J P. "一种14:0-16:0 PC的合成方法" [P]. US Patent, US 10581453 B2, 2023-05-23.
- Kumar R, Park J H, O'Brien P Q. "Method for the Synthesis of (2R)-2-(hexadecanoyloxy)-3-(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate 1-Myristoyl-2-palmitoylphosphatidylcholine 1-myristoyl-2-palmitoyl-GPC 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoylphosphatidylcholine 69525-80-0 CHEBI:75062 GPC(14:0/16:0) MPPC PC(14:0/16:0) PC(30:0) Phosphatidylcholine(14:0/16:0) Phosphatidylcholine(30:0)" [P]. US Patent, US 10051685 B2, 2025-05-23.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 14:0-16:0 PC in Pharmaceutical Formulations". Environ. Sci. Technol., 2024, 735, 4105-4132.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 14:0-16:0 PC as an Impurity". J. Nat. Prod., 2012, 382, (10), 3475-3493.
- Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (2R)-2-(hexadecanoyloxy)-3-(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate 1-Myristoyl-2-palmitoylphosphatidylcholine 1-myristoyl-2-palmitoyl-GPC 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine 1-tetradecanoyl-2-hexadecanoylphosphatidylcholine 69525-80-0 CHEBI:75062 GPC(14:0/16:0) MPPC PC(14:0/16:0) PC(30:0) Phosphatidylcholine(14:0/16:0) Phosphatidylcholine(30:0) Using HRMS and NMR". Sci. Total Environ., 2021, 1102, (7), 8522-8529.
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