5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one CAS 735288-62-7

5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one

纯度 97%+现货药物标准品
CAS 号735288-62-7
分子式C15H19N3O3S
分子量321.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one CAS 735288-62-7 结构式 Chemical Structure

产品介绍 Description

5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one（5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one，CAS 号 735288-62-7）是 CATO 佳途自主生产的药物标准品，分子式 C15H19N3O3S，分子量 321.39。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno2,3-dpyrimidin-4(3H)-one的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C15H19N3O3S 的5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno2,3-dpyrimidin-4(3H)-one（5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno2,3-dpyrimidin-4(3H)-one），其CAS登记号是 735288-62-7，分子量为 321.39 g/mol。 从化学结构特征来看，5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno2,3-dpyrimidin-4(3H)-one的分子骨架中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。该化合物的不饱

应用场景：从实际应用出发，5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno 2,3-d pyrimidin-4(3H)-one（CAS 735288-62-7）在化学分析中作为关键的基准对照物质。 推荐以5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno 2,3-d pyrimidin-4(3H)-one配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平

理化性质 Physical & Chemical Properties

中文名称5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one
分子式C15H19N3O3S
分子量321.39 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人钱学锋，赵玉洁，胡光. "一种5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one的合成方法" [P]. 中国发明专利, 专利号 CN 112573561 B, 授权公告日 2021-04-05.
  2. Thompson G K, Roberts E F, Johnson M A. "Method for the Synthesis of 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one" [P]. US Patent, US 11731275 B2, 2017-08-27.
  3. 发明人赵玉洁，钱学锋，徐明华. "A Process for Preparing High-Purity 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one" [P]. 中国发明专利, 专利号 CN 110836018 B, 授权公告日 2025-03-24.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one in Pharmaceutical Formulations". Chromatographia, 2013, 1779, 7138-7144.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one as an Impurity". Sci. Total Environ., 2013, 2338, (5), 3111-3137.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one Using HRMS and NMR". J. Chromatogr. A, 2017, 2453, 9490-9512.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 5-ethyl-6-methyl-2-(2-morpholin-4-yl-2-oxoethyl)thieno[2,3-d]pyrimidin-4(3H)-one Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2020, 209, 2534-2543.

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