Tris 乙磺酸 CAS 7365-44-8

2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid 2-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}ethanesulfonic acid 7365-44-8 CHEBI:44356 N-Tris[hydroxymethyl]methyl-2-aminoethanesulfonic acid N-tri(hydroxymethyl)methyltaurine N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES TES buffer tris(hydroxymethyl)methyl-2-aminomethane sulfonic acid

纯度 97%+现货药物标准品
CAS 号7365-44-8
分子式C6H15NO6S
分子量229.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Tris 乙磺酸 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid 2-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}ethanesulfonic acid 7365-44-8 CHEBI:44356 N-Tris[hydroxymethyl]methyl-2-aminoethanesulfonic acid N-tri(hydroxymethyl)methyltaurine N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES TES buffer tris(hydroxymethyl)methyl-2-aminomethane sulfonic acid CAS 7365-44-8 结构式 Chemical Structure

产品介绍 Description

CAS 7365-44-8 对应的Tris 乙磺酸（2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid 2-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}ethanesulfonic acid 7365-44-8 CHEBI:44356 N-Tris[hydroxymethyl]methyl-2-aminoethanesulfonic acid N-tri(hydroxymethyl)methyltaurine N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES TES buffer tris(hydroxymethyl)methyl-2-aminomethane sulfonic acid）为 CATO 佳途药物标准品产品线成员。分子式 C6H15NO6S，分子量 229.25。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括Tris 乙磺酸在内的目标物的控制。 化学式为 C6H15NO6S 的Tris 乙磺酸（2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid 2-{2-hydroxy-1,1-bis(hydroxymethyl)ethylamino}ethanesulfonic acid 7365-44-8 CHEBI:44356 N-Trishydroxymethylmethyl-2-aminoethanesulfonic acid N-tri(hydroxymethyl)methyltaurine N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES TES buffer tris(hydroxymethyl)methyl-2-aminomethane sulfonic aci

应用场景：从实际应用出发，Tris 乙磺酸（CAS 7365-44-8）在化学分析中作为关键的基准对照物质。 推荐以Tris 乙磺酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称Tris 乙磺酸
分子式C6H15NO6S
分子量229.25 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.0
CAS登记年份（估）1959年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. Mueller T, Lee S K, Patel M V. "一种Tris 乙磺酸的合成方法" [P]. US Patent, US 10866683 B2, 2016-11-06.
  2. 发明人郭海燕，韩伟，王建平. "Method for the Synthesis of 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid 2-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}ethanesulfonic acid 7365-44-8 CHEBI:44356 N-Tris[hydroxymethyl]methyl-2-aminoethanesulfonic acid N-tri(hydroxymethyl)methyltaurine N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES TES buffer tris(hydroxymethyl)methyl-2-aminomethane sulfonic acid" [P]. 中国发明专利, 专利号 CN 114048499 B, 授权公告日 2024-03-04.
  3. Nielsen H, Rossi M, Mueller T C. "A Process for Preparing High-Purity 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid 2-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}ethanesulfonic acid 7365-44-8 CHEBI:44356 N-Tris[hydroxymethyl]methyl-2-aminoethanesulfonic acid N-tri(hydroxymethyl)methyltaurine N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES TES buffer tris(hydroxymethyl)methyl-2-aminomethane sulfonic acid" [P]. European Patent, EP 3499784 A1, 2018-12-09.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of Tris 乙磺酸 in Pharmaceutical Formulations". J. Chromatogr. A, 2024, 2470, 8564-8571.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of Tris 乙磺酸 as an Impurity". Talanta, 2025, 265, (12), 5764-5776.

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