2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one CAS 736948-77-9

2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

纯度 97%+现货药物标准品
CAS 号736948-77-9
分子式C16H21N3OS
分子量303.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one 2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one CAS 736948-77-9 结构式 Chemical Structure

产品介绍 Description

2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one（2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one，CAS 号 736948-77-9）是 CATO 佳途自主生产的药物标准品，分子式 C16H21N3OS，分子量 303.42。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

作为认证标准物质（CRM），2-(4-methylpiperidin-1-yl)methyl-3,5,6,7-tetrahydro-4H-cyclopenta4,5thieno2,3-dpyrimidin-4-one满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C16H21N3OS 的2-(4-methylpiperidin-1-yl)methyl-3,5,6,7-tetrahydro-4H-cyclopenta4,5thieno2,3-dpyrimidin-4-one（2-(4-methylpiperidin-1-yl)methyl-3,5,6,7-tetrahydro-4H-cyclopenta4,5thieno2,3-dpyrimidin-4-one），其CAS登记号是 736948-77-9，分子量为 303.42 g/mol。 2-(4-methylpiperidin-1-yl)me

应用场景：针对化学分析用途，2- (4-methylpiperidin-1-yl)methyl -3,5,6,7-tetrahydro-4H-cyclopenta 4,5 thieno 2,3-d pyrimidin-4-one（2- (4-methylpiperidin-1-yl)methyl -3,5,6,7-tetrahydro-4H-cyclopenta 4,5 thieno 2,3-d pyrimidin-4-one）是具有明确定量溯源的认证级对照品。 推荐以2- (4-methylpiperidin-1-yl)methyl -3,5,6,7-tetrahydro-4H-cyclopenta

理化性质 Physical & Chemical Properties

中文名称2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one
分子式C16H21N3OS
分子量303.42 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. Mueller T C, Schröder R, Martínez F. "一种2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one的合成方法" [P]. European Patent, EP 3286182 A1, 2017-02-18.
  2. 发明人冯建国，高志强，刘建华. "Method for the Synthesis of 2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one" [P]. 中国发明专利, 专利号 CN 117775095 B, 授权公告日 2016-07-06.
  3. 发明人朱建伟，王建平，马晓峰. "A Process for Preparing High-Purity 2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one" [P]. 中国发明专利, 专利号 CN 110625892 B, 授权公告日 2025-03-09.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one in Pharmaceutical Formulations". Biomed. Chromatogr., 2015, 2323, (4), 1115-1141.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as an Impurity". J. Nat. Prod., 2019, 1832, (4), 3603-3624.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 2-[(4-methylpiperidin-1-yl)methyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one Using HRMS and NMR". Phytochemistry, 2018, 1902, 7713-7732.

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