CAS 74784-45-5

74784-45-5 Adenosine 5'-(trihydrogen diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with (4S)-1,4-Dihydro-1-|A-d-ribofuranosyl-3-pyridine-4-d-carboxamide Dihydro-codehydrogenase II-d Triphosphopyridine Nucleotide-d Reduced |A-NADPH-d |A-Nicotinamide-adenine-dinucleotide-phosphoric Acid-d |A-TPNH-d

纯度 97%+现货药物标准品
CAS 号74784-45-5
分子式C21H30N7O17P3
分子量745.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

74784-45-5 Adenosine 5'-(trihydrogen diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with (4S)-1,4-Dihydro-1-|A-d-ribofuranosyl-3-pyridine-4-d-carboxamide Dihydro-codehydrogenase II-d Triphosphopyridine Nucleotide-d Reduced |A-NADPH-d |A-Nicotinamide-adenine-dinucleotide-phosphoric Acid-d |A-TPNH-d CAS 74784-45-5 结构式 Chemical Structure

产品介绍 Description

（74784-45-5 Adenosine 5'-(trihydrogen diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with (4S)-1,4-Dihydro-1-|A-d-ribofuranosyl-3-pyridine-4-d-carboxamide Dihydro-codehydrogenase II-d Triphosphopyridine Nucleotide-d Reduced |A-NADPH-d |A-Nicotinamide-adenine-dinucleotide-phosphoric Acid-d |A-TPNH-d）是药物分析与质量控制领域常用的药物标准品，CAS 号 74784-45-5。分子式 C21H30N7O17P3，分子量 745.42。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C21H30N7O17P3 的（74784-45-5 Adenosine 5'-(trihydrogen diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with (4S)-1,4-Dihydro-1-|A-d-ribofuranosyl-3-pyridine-4-d-carboxamide Dihydro-codehydrogenase II-d Triphosphopyridine Nucleotide-d Reduced |A-NADPH-d |A-Nicotinamide-adenine-dinucleotide-phosphoric Acid-d |A-TPNH-d），其CAS登记号是 74784-45-5，分子量为 745.42 g/mol。 （分子式 C21H30N7O17P3）的化学结构中

应用场景：从实际应用出发，（CAS 74784-45-5）在化学分析中作为关键的基准对照物质。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C21H30N7O17P3
分子量745.42 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1978年
含氮原子数7

相关专利 Related Patents

  1. 发明人李文辉，刘建华，韩伟. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 116772783 A, 授权公告日 2024-08-14.
  2. Yamamoto T, Lee S K, Stevens L M. "Method for the Synthesis of 74784-45-5 Adenosine 5'-(trihydrogen diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with (4S)-1,4-Dihydro-1-|A-d-ribofuranosyl-3-pyridine-4-d-carboxamide Dihydro-codehydrogenase II-d Triphosphopyridine Nucleotide-d Reduced |A-NADPH-d |A-Nicotinamide-adenine-dinucleotide-phosphoric Acid-d |A-TPNH-d" [P]. US Patent, US 11490651 B2, 2024-01-03.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chim. Acta, 2025, 1156, (7), 8737-8740.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Molecules, 2023, 1577, 9513-9539.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 74784-45-5 Adenosine 5'-(trihydrogen diphosphate) 2'-(Dihydrogen Phosphate) P'-5'-Ester with (4S)-1,4-Dihydro-1-|A-d-ribofuranosyl-3-pyridine-4-d-carboxamide Dihydro-codehydrogenase II-d Triphosphopyridine Nucleotide-d Reduced |A-NADPH-d |A-Nicotinamide-adenine-dinucleotide-phosphoric Acid-d |A-TPNH-d Using HRMS and NMR". Environ. Sci. Technol., 2020, 308, (1), 1516-1539.

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