Begacestat CAS 769169-27-9

769169-27-9 3666C56BBU Begacestat [USAN:INN] 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56BBU

纯度 97%+现货药物标准品
CAS 号769169-27-9
分子式C9H12ClF6NO3S2
分子量395.77 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Begacestat 769169-27-9 3666C56BBU Begacestat [USAN:INN] 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56BBU CAS 769169-27-9 结构式 Chemical Structure

产品介绍 Description

Begacestat（英文名 769169-27-9 3666C56BBU Begacestat [USAN:INN] 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56BBU，CAS 769169-27-9）属于药物标准品。分子式 C9H12ClF6NO3S2，分子量 395.77。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，Begacestat的分子量为395.77 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 769169-27-9 对应的化合物Begacestat（英文标识 769169-27-9 3666C56BBU Begacestat USAN:INN 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56BBU），化学式 C9H12ClF6NO3S2，相对分子质量 395.77。 依据分子式为 C9H12ClF6NO3S2 的Begacestat结构特征，其分子内含酰胺类，含砜基，羧酸类，含羟基，含醚键，含氟/氯取代，这

应用场景：针对化学分析用途，Begacestat（769169-27-9 3666C56BBU Begacestat USAN:INN 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56

理化性质 Physical & Chemical Properties

中文名称Begacestat
分子式C9H12ClF6NO3S2
分子量395.77 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1986年
卤素含量F/Cl取代
含氮原子数1
含硫原子数2

相关专利 Related Patents

  1. 发明人张德明，赵玉洁，朱建伟. "一种Begacestat的合成方法" [P]. 中国发明专利, 专利号 CN 115293115 B, 授权公告日 2021-03-17.
  2. 发明人周伟，韩伟，郭海燕. "Method for the Synthesis of 769169-27-9 3666C56BBU Begacestat [USAN:INN] 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56BBU" [P]. 中国发明专利, 专利号 CN 112116742 B, 授权公告日 2022-03-17.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of Begacestat in Pharmaceutical Formulations". Anal. Chim. Acta, 2019, 1000, (9), 3883-3890.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of Begacestat as an Impurity". Talanta, 2014, 2426, (4), 4903-4911.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 769169-27-9 3666C56BBU Begacestat [USAN:INN] 2-Thiophenesulfonamide, 5-chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)- Begacestat GSI-953 5-Chloro-N-((1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl)thiophene-2-sulfonamide UNII-3666C56BBU Using HRMS and NMR". Anal. Chem., 2016, 932, (12), 466-473.

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