<I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇 CAS 79069-14-0
(s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-valinol boc-val-ol boc-valinol n-(tert-butoxycarbonyl)-l-valinol n-alpha-t-butyloxycarbonyl-l-valinol n-alpha-tert-butyloxycarbonyl-l-valinol n-t-boc-l-valinol n-tboc-l-valinol n-tert-butoxycarbonyl-l-valinol
| CAS 号 | 79069-14-0 |
| 分子式 | C10H21NO3 |
| 分子量 | 203.28 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
<I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇（(s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-valinol boc-val-ol boc-valinol n-(tert-butoxycarbonyl)-l-valinol n-alpha-t-butyloxycarbonyl-l-valinol n-alpha-tert-butyloxycarbonyl-l-valinol n-t-boc-l-valinol n-tboc-l-valinol n-tert-butoxycarbonyl-l-valinol，CAS 号 79069-14-0）是 CATO 佳途自主生产的药物标准品，分子式 C10H21NO3，分子量 203.28。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C10H21NO3 的<I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇（(s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-valinol boc-val-ol boc-
应用场景：<I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇（(s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-v
理化性质 Physical & Chemical Properties
| 中文名称 | <I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇 |
| 分子式 | C10H21NO3 |
| 分子量 | 203.28 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1979年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人周伟，唐晓军，何建平. "一种<I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇的合成方法" [P]. 中国发明专利, 专利号 CN 108010591 A, 授权公告日 2016-05-03.
- 发明人赵玉洁，高志强，张德明. "Method for the Synthesis of (s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-valinol boc-val-ol boc-valinol n-(tert-butoxycarbonyl)-l-valinol n-alpha-t-butyloxycarbonyl-l-valinol n-alpha-tert-butyloxycarbonyl-l-valinol n-t-boc-l-valinol n-tboc-l-valinol n-tert-butoxycarbonyl-l-valinol" [P]. 中国发明专利, 专利号 CN 111875838 B, 授权公告日 2015-05-10.
- Fischer A B, Klinger H, Patel M V. "A Process for Preparing High-Purity (s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-valinol boc-val-ol boc-valinol n-(tert-butoxycarbonyl)-l-valinol n-alpha-t-butyloxycarbonyl-l-valinol n-alpha-tert-butyloxycarbonyl-l-valinol n-t-boc-l-valinol n-tboc-l-valinol n-tert-butoxycarbonyl-l-valinol" [P]. US Patent, US 11889129 B2, 2023-05-18.
参考文献 Literature
- Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2019, 1110, 1646-1655.
- Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>-(叔丁氧基羰基)-<SC>L</SC>-缬氨醇 as an Impurity". Molecules, 2023, 2329, 6450-6460.
- Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of (s)-(-)-2-(boc-amino)-3-methyl-1-butanol (s)-(-)-boc-valinol (s)-2-(tertbutoxycarbonylamino)-3-methylbutanol (s)-n-(tert-butoxycarbonyl)-valinol (s)-n-(tert-butoxycarbonyl)valinol (s)-tert-butyl 1-hydroxy-3-methylbutan-2-ylcarbamate 79069-14-0 N-Boc-L-valinol boc-l-valinol boc-val-ol boc-valinol n-(tert-butoxycarbonyl)-l-valinol n-alpha-t-butyloxycarbonyl-l-valinol n-alpha-tert-butyloxycarbonyl-l-valinol n-t-boc-l-valinol n-tboc-l-valinol n-tert-butoxycarbonyl-l-valinol Using HRMS and NMR". Talanta, 2018, 1284, (8), 7508-7511.
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