18:1-12:0 Biotin PIP3 CAS 799812-70-7

799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris[(hydroxyphosphinato)oxy]cyclohexyl (2R)-3-{[(9Z)-octadec-9-enoyl]oxy}-2-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecanoyl]oxy}propyl phosphate DTXSID00677059

纯度 97%+现货药物标准品
CAS 号799812-70-7
分子式C49H87N3O24P4S 4*Na
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

18:1-12:0 Biotin PIP3 799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris[(hydroxyphosphinato)oxy]cyclohexyl (2R)-3-{[(9Z)-octadec-9-enoyl]oxy}-2-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecanoyl]oxy}propyl phosphate DTXSID00677059 CAS 799812-70-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品18:1-12:0 Biotin PIP3（799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris[(hydroxyphosphinato)oxy]cyclohexyl (2R)-3-{[(9Z)-octadec-9-enoyl]oxy}-2-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecanoyl]oxy}propyl phosphate DTXSID00677059，CAS 799812-70-7），分子式 C49H87N3O24P4S 4*Na。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

18:1-12:0 Biotin PIP3（分子式 C49H87N3O24P4S 4Na）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含磷酸酯基，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 18:1-12:0 Biotin PIP3（799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris(hydroxyphosphinato)oxycyclohexyl (2R)-3-{(9Z)-octadec-9-enoyloxy}-2-{12-({5-(3aS,4S,6aR)-2-oxohexahydro-1H-thieno3,4-dimidazol-4-ylpentanoyl}amino)dodecanoyloxy}propyl phosphate DTXSID00677059），CAS注册编号 799812-70-7，化学分子式

应用场景：18:1-12:0 Biotin PIP3（799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris (hydroxyphosphinato)oxy cyclohexyl (2R)-3-{ (9Z)-octadec-9-enoyl oxy}-2-{ 12-({5- (3aS,4S,6aR)-2-oxohexahydro-1H-thieno 3,4-d imidazol-4-yl pentanoyl}amino)dodecanoyl oxy}propyl phosphate DTXSID00677059，CAS 799812-70-7）的标准化应

理化性质 Physical & Chemical Properties

中文名称18:1-12:0 Biotin PIP3
分子式C49H87N3O24P4S 4*Na
分子量1281.18 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. Chen K W, Anderson J P, Brown S R. "一种18:1-12:0 Biotin PIP3的合成方法" [P]. US Patent, US 9507491 B2, 2016-08-28.
  2. 发明人胡光，孙丽萍，王建平. "Method for the Synthesis of 799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris[(hydroxyphosphinato)oxy]cyclohexyl (2R)-3-{[(9Z)-octadec-9-enoyl]oxy}-2-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecanoyl]oxy}propyl phosphate DTXSID00677059" [P]. 中国发明专利, 专利号 CN 114022629 A, 授权公告日 2024-01-22.
  3. Patel M V, Klinger H, Stevens L M. "A Process for Preparing High-Purity 799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris[(hydroxyphosphinato)oxy]cyclohexyl (2R)-3-{[(9Z)-octadec-9-enoyl]oxy}-2-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecanoyl]oxy}propyl phosphate DTXSID00677059" [P]. US Patent, US 11656529 B2, 2024-01-22.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 18:1-12:0 Biotin PIP3 in Pharmaceutical Formulations". Anal. Chim. Acta, 2018, 767, 9362-9389.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 18:1-12:0 Biotin PIP3 as an Impurity". Food Chem., 2014, 1340, 4949-4965.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 799812-70-7 Tetrasodium (3S)-2,6-dihydroxy-3,4,5-tris[(hydroxyphosphinato)oxy]cyclohexyl (2R)-3-{[(9Z)-octadec-9-enoyl]oxy}-2-{[12-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)dodecanoyl]oxy}propyl phosphate DTXSID00677059 Using HRMS and NMR". J. Sep. Sci., 2021, 1620, (2), 6417-6444.

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