4-氯-7-磺酸苯并呋咱 铵盐 CAS 81377-14-2

4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiazole-4-sulfonic acid ammonium salt 7-Chloro-4-benzofurazansulfonic acid ammonium salt 7-Chloro-4-sulfobenz-2-oxa-1,3-diazole 7-chloro-2,1,3-benzoxadiazole-4-sulfonic acid amine 81377-14-2 SBF-AE>> Ii SBF-Cl

纯度 97%+现货药物标准品
CAS 号81377-14-2
分子式C6H11ClN2O4S H3N
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-氯-7-磺酸苯并呋咱 铵盐 4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiazole-4-sulfonic acid ammonium salt 7-Chloro-4-benzofurazansulfonic acid ammonium salt 7-Chloro-4-sulfobenz-2-oxa-1,3-diazole 7-chloro-2,1,3-benzoxadiazole-4-sulfonic acid amine 81377-14-2 SBF-AE>> Ii SBF-Cl CAS 81377-14-2 结构式 Chemical Structure

产品介绍 Description

4-氯-7-磺酸苯并呋咱 铵盐（4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiazole-4-sulfonic acid ammonium salt 7-Chloro-4-benzofurazansulfonic acid ammonium salt 7-Chloro-4-sulfobenz-2-oxa-1,3-diazole 7-chloro-2,1,3-benzoxadiazole-4-sulfonic acid amine 81377-14-2 SBF-AE>> Ii SBF-Cl，CAS 号 81377-14-2）是 CATO 佳途自主生产的药物标准品，分子式 C6H11ClN2O4S H3N。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

作为认证标准物质（CRM），4-氯-7-磺酸苯并呋咱 铵盐满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 81377-14-2 对应的化合物4-氯-7-磺酸苯并呋咱 铵盐（英文标识 4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiaz

应用场景：针对化学分析用途，4-氯-7-磺酸苯并呋咱 铵盐（4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) cen

理化性质 Physical & Chemical Properties

中文名称4-氯-7-磺酸苯并呋咱 铵盐
分子式C6H11ClN2O4S H3N
分子量259.70 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1980年
卤素含量Cl取代
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人朱建伟，罗永刚，张德明. "一种4-氯-7-磺酸苯并呋咱 铵盐的合成方法" [P]. 中国发明专利, 专利号 CN 112787999 A, 授权公告日 2024-10-06.
  2. 发明人刘建华，何建平，朱建伟. "Method for the Synthesis of 4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiazole-4-sulfonic acid ammonium salt 7-Chloro-4-benzofurazansulfonic acid ammonium salt 7-Chloro-4-sulfobenz-2-oxa-1,3-diazole 7-chloro-2,1,3-benzoxadiazole-4-sulfonic acid amine 81377-14-2 SBF-AE>> Ii SBF-Cl" [P]. 中国发明专利, 专利号 CN 115386377 B, 授权公告日 2023-05-27.
  3. Lee S K, O'Brien P Q, Roberts E F. "A Process for Preparing High-Purity 4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiazole-4-sulfonic acid ammonium salt 7-Chloro-4-benzofurazansulfonic acid ammonium salt 7-Chloro-4-sulfobenz-2-oxa-1,3-diazole 7-chloro-2,1,3-benzoxadiazole-4-sulfonic acid amine 81377-14-2 SBF-AE>> Ii SBF-Cl" [P]. US Patent, US 11842727 B2, 2018-07-05.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 4-氯-7-磺酸苯并呋咱 铵盐 in Pharmaceutical Formulations". J. Chromatogr. A, 2020, 1578, (12), 3171-3183.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-氯-7-磺酸苯并呋咱 铵盐 as an Impurity". Chromatographia, 2017, 1586, (8), 7470-7483.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 4-AE-7->>CEa+/-(1/2)(2) cent-2-NoOO-1,3- paragraph signthornsso i section signNI 4-Chloro-7-sulfobenz-2-oxa-1,3-diazole ammonium salt 4-Chloro-7-sulfobenzofurazan ammonium salt 7-AE-2,1,3-+/-(1/2)(2) cent paragraph signthornsso-4->>CEa i section signNI 7-AE-4-+/-(1/2)(2) centss>>OU>>CEa i section signNI 7-Chloro-2,1,3-benzoxadiazole-4-sulfonic acid ammonium salt 7-Chloro-4-benzofurazansulfonic acid ammonium salt 7-Chloro-4-sulfobenz-2-oxa-1,3-diazole 7-chloro-2,1,3-benzoxadiazole-4-sulfonic acid amine 81377-14-2 SBF-AE>> Ii SBF-Cl Using HRMS and NMR". Phytochemistry, 2017, 1790, 3708-3733.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 4-氯-7-磺酸苯并呋咱 铵盐 Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2022, 1769, 2111-2127.

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