CAS 81965-43-7

BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-BHB013S3MO

纯度 97%+现货药物标准品
CAS 号81965-43-7
分子式C6H11ClN4O3
分子量222.63 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-BHB013S3MO CAS 81965-43-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-BHB013S3MO，CAS 81965-43-7），分子式 C6H11ClN4O3，分子量 222.63。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 化学式为 C6H11ClN4O3 的（BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-B

应用场景：（BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-n

理化性质 Physical & Chemical Properties

中文名称
分子式C6H11ClN4O3
分子量222.63 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1980年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人刘建华，冯建国，赵玉洁. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 109961325 B, 授权公告日 2022-03-07.
  2. 发明人沈红梅，周伟，赵玉洁. "Method for the Synthesis of BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-BHB013S3MO" [P]. 中国发明专利, 专利号 CN 112579307 A, 授权公告日 2021-12-02.
  3. Nielsen H, Nowak P, Sørensen M. "A Process for Preparing High-Purity BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-BHB013S3MO" [P]. European Patent, EP 3976604 A1, 2016-02-17.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Food Chem., 2018, 1630, 4223-4235.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chim. Acta, 2021, 1345, (5), 2157-2164.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of BHB013S3MO 81965-43-7 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)propanamide Acetamide, 2-((((2-chloroethyl)nitrosoamino)carbonyl)methylamino)- 1-(Carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitrosourea NSC 364432 Sarcosinamide chloroethyl nitrosourea SarCNU 2-Chloroethyl-3-sarcosinamide-1-nitrosourea CCRIS 9380 Sarcosinamide chloroethylnitrosourea Sarmustine Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-1-methyl-3-nitroso- UNII-BHB013S3MO Using HRMS and NMR". J. Nat. Prod., 2011, 647, (12), 1686-1689.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2021, 321, 7837-7844.

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