ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate CAS 827594-59-2

ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate

纯度 97%+现货药物标准品
CAS 号827594-59-2
分子式C19H22F3N3O2
分子量381.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate CAS 827594-59-2 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate（ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate）为药物标准品，CAS 登记号 827594-59-2，分子式 C19H22F3N3O2，分子量 381.39。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo1,5-apyrimidine-2-carboxylate在内的目标物的控制。 化学式为 C19H22F3N3O2 的ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo1,5-apyrimidine-2-carboxylate（ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo1,5-apyrimidine-2-carboxylate），其CAS登记号是 827594-59-2，分子量为 381.39 g/mol。 ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo1,5-a

应用场景：在化学分析实验室中，ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo 1,5-a pyrimidine-2-carboxylate（CAS 827594-59-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo 1,5-a pyrimidine-2-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建

理化性质 Physical & Chemical Properties

中文名称ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate
分子式C19H22F3N3O2
分子量381.39 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Mueller T, Roberts E F, O'Brien P Q. "一种ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate的合成方法" [P]. US Patent, US 9778726 B2, 2016-03-26.
  2. 发明人钱学锋，冯建国，周伟. "Method for the Synthesis of ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate" [P]. 中国发明专利, 专利号 CN 113444843 B, 授权公告日 2021-01-20.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate in Pharmaceutical Formulations". J. Chromatogr. A, 2016, 412, 5878-5891.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate as an Impurity". Biomed. Chromatogr., 2018, 2455, (4), 5443-5471.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate Using HRMS and NMR". Food Chem., 2012, 252, (6), 3579-3598.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate ethyl 5-(4-isopropylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-2-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2020, 1838, (12), 2292-2299.

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