methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 828298-30-2

methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

纯度 97%+现货药物标准品
CAS 号828298-30-2
分子式C16H20N4O5S
分子量380.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 828298-30-2 结构式 Chemical Structure

产品介绍 Description

CAS 828298-30-2 对应的methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C16H20N4O5S，分子量 380.42。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，methyl 4-4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate的分子量为380.42 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 828298-30-2 对应的化合物methyl 4-4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（英文标识 methyl 4-4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate），化学式 C16H20N4O5S，相对分子质量 380.42。 受分子结构中黄酮骨架，酰胺类，含砜基，含羟基，含醚键的影响，me

应用场景：methyl 4- 4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl -6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（methyl 4- 4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl -6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以methyl 4- 4-(2-hydrazino-2-oxoethoxy)

理化性质 Physical & Chemical Properties

中文名称methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
分子式C16H20N4O5S
分子量380.42 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人何建平，李文辉，黄志刚. "一种methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 116896003 B, 授权公告日 2018-06-13.
  2. 发明人黄志刚，高志强，韩伟. "Method for the Synthesis of methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate" [P]. 中国发明专利, 专利号 CN 113903050 A, 授权公告日 2015-07-21.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2010, 2374, 1326-1339.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate as an Impurity". J. Chromatogr. A, 2021, 2379, (3), 5516-5519.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Using HRMS and NMR". Phytochemistry, 2020, 776, (4), 8093-8113.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate methyl 4-[4-(2-hydrazino-2-oxoethoxy)-3-methoxyphenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2021, 129, 1959-1970.

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