五氟苯磺酰氯 CAS 832-53-1

(4R)-N-(2-aminoethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide (4R)-N-(2-azanylethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide 832-53-1 A840542

纯度 97%+现货药物标准品
CAS 号832-53-1
分子式C6H6ClF5O2S
分子量272.62 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

五氟苯磺酰氯 (4R)-N-(2-aminoethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide (4R)-N-(2-azanylethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide 832-53-1 A840542 CAS 832-53-1 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的五氟苯磺酰氯（(4R)-N-(2-aminoethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide (4R)-N-(2-azanylethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide 832-53-1 A840542）为药物标准品，CAS 登记号 832-53-1，分子式 C6H6ClF5O2S，分子量 272.62。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

化学式为 C6H6ClF5O2S 的五氟苯磺酰氯（(4R)-N-(2-aminoethyl)-4-(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopentaaphenanthren-17-ylpentanamide (4R)-N-(2-azanylethyl)-4-(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopentaaphenanthren-17-ylpentanamide 832-53-1 A840542），其CAS登记号是 832-53-1，分子量为 272.62 g/mol。 五氟苯磺酰氯（C6H6ClF5O2S）含有含砜基，羧酸类，含羟基，含

应用场景：从实际应用出发，五氟苯磺酰氯（CAS 832-53-1）在化学分析中作为关键的基准对照物质。 推荐以五氟苯磺酰氯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于室温保存，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称五氟苯磺酰氯
分子式C6H6ClF5O2S
分子量272.62 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
卤素含量F/Cl取代
含硫原子数1

相关专利 Related Patents

  1. 发明人郑宇鹏，刘建华，王建平. "一种五氟苯磺酰氯的合成方法" [P]. 中国发明专利, 专利号 CN 116990924 A, 授权公告日 2020-04-20.
  2. Park J H, Fischer A B, Mueller T. "Method for the Synthesis of (4R)-N-(2-aminoethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide (4R)-N-(2-azanylethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide 832-53-1 A840542" [P]. US Patent, US 9297700 B2, 2023-04-19.
  3. 发明人罗永刚，冯建国，黄志刚. "A Process for Preparing High-Purity (4R)-N-(2-aminoethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide (4R)-N-(2-azanylethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide 832-53-1 A840542" [P]. 中国发明专利, 专利号 CN 108542093 B, 授权公告日 2023-12-12.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 五氟苯磺酰氯 in Pharmaceutical Formulations". Anal. Chim. Acta, 2017, 2466, (11), 3254-3284.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 五氟苯磺酰氯 as an Impurity". Phytochemistry, 2025, 2272, 6535-6540.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of (4R)-N-(2-aminoethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide (4R)-N-(2-azanylethyl)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17S)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide 832-53-1 A840542 Using HRMS and NMR". J. Sep. Sci., 2018, 1136, (5), 9263-9283.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 五氟苯磺酰氯 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2010, 832, (7), 4690-4708.

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