2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile CAS 848369-68-6

2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile

纯度 97%+现货药物标准品
CAS 号848369-68-6
分子式C14H16N2O2
分子量244.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile CAS 848369-68-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile（2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile）为药物标准品，CAS 登记号 848369-68-6，分子式 C14H16N2O2，分子量 244.29。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C14H16N2O2 的2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile（2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile），其CAS登记号是 848369-68-6，分子量为 244.29 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile表现为淡黄色至黄色结晶性粉末。其固体形态的物理化学属性——包括244.29 g/mol的分子量——对于选择

应用场景：针对化学分析用途，2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile（2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile）是具有明确定量溯源的认证级对照品。 推荐以2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储

理化性质 Physical & Chemical Properties

中文名称2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile
分子式C14H16N2O2
分子量244.29 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数2

相关专利 Related Patents

  1. 发明人马晓峰，张德明，沈红梅. "一种2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile的合成方法" [P]. 中国发明专利, 专利号 CN 116148540 A, 授权公告日 2017-02-02.
  2. Patel M V, Yamamoto T, Mueller T. "Method for the Synthesis of 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile" [P]. US Patent, US 11627085 B2, 2024-08-23.
  3. Rossi M, Lefèvre J P, Mueller T C. "A Process for Preparing High-Purity 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile" [P]. European Patent, EP 3457842 A1, 2016-04-24.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile in Pharmaceutical Formulations". Biomed. Chromatogr., 2011, 1890, (9), 2992-3015.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile as an Impurity". Phytochemistry, 2024, 894, 2107-2116.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile Using HRMS and NMR". Anal. Methods, 2014, 584, (9), 684-692.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-(1-hydroxyethyl)-5-methyl-3-furonitrile Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2014, 1014, (11), 4164-4178.

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