5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid CAS 849068-61-7
1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO[5,4-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965
| CAS 号 | 849068-61-7 |
| 分子式 | C8H13BrN2O2 |
| 分子量 | 249.11 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid（英文名 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO[5,4-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965，CAS 849068-61-7）属于药物标准品。分子式 C8H13BrN2O2，分子量 249.11。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-Bromo-1H-pyrrolo2,3-bpyridine-3-carboxylic acid在内的目标物的控制。 5-Bromo-1H-pyrrolo2,3-bpyridine-3-carboxylic acid（1H-PYRROLO2,3-BPYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO2,3-BPYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO5,4-BPYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965），CAS注册编号 849068-61-7，化学分子式为 C8H13BrN2O2，分子量 249.11 g/mol。 5-Bromo-1H-pyrrolo2,3-bpyridine-3-carboxylic acid（分子式
应用场景：5-Bromo-1H-pyrrolo 2,3-b pyridine-3-carboxylic acid（1H-PYRROLO 2,3-B PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO 2,3-B PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO 5,4-B PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965）作为药物标准品，
理化性质 Physical & Chemical Properties
| 中文名称 | 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid |
| 分子式 | C8H13BrN2O2 |
| 分子量 | 249.11 g/mol |
| 外观形态 | 白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1987年 |
| 卤素含量 | Br取代 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人郑宇鹏，沈红梅，赵玉洁. "一种5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115412800 B, 授权公告日 2018-02-06.
- 发明人王建平，朱建伟，周伟. "Method for the Synthesis of 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO[5,4-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965" [P]. 中国发明专利, 专利号 CN 110375457 B, 授权公告日 2019-07-01.
- O'Brien P Q, Lee S K, Fischer A B. "A Process for Preparing High-Purity 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO[5,4-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965" [P]. US Patent, US 9986076 B2, 2019-11-13.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid in Pharmaceutical Formulations". Phytochemistry, 2022, 331, (10), 8557-8567.
- Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid as an Impurity". Environ. Sci. Technol., 2024, 1905, 106-114.
- Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-1H-PYRROLO[5,4-B]PYRIDINE-3-CARBOXYLIC ACID 5-BROMO-7-AZAINDOLE-3-CARBOXYLIC ACID 849068-61-7 ABBYPHARMA AP-14-10708 BC003965 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2018, 1257, 3539-3542.
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