2-甲基噁唑-4-甲酸甲酯 CAS 85806-67-3

2-methyl-oxazole-4-carboxylic acid methyl ester 2-methyl-oxazole-4-carboxylic aicd methyl ester 4-methyl-3,5-oxazolecarboxylic acid methyl ester 4-oxazolecarboxylic acid, 2-methyl-, methyl ester 4-oxazolecarboxylicacid,2-methyl-,methylester(9ci) 85806-67-3 Methyl 2-methyloxazole-4-carboxylate methyl 2-methyl-1,3-oxazole-4-carboxylate methyl-4-methyl-3,5-oxazolecarboxylate

纯度 97%+现货药物标准品
CAS 号85806-67-3
分子式C6H11NO3
分子量145.16 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-甲基噁唑-4-甲酸甲酯 2-methyl-oxazole-4-carboxylic acid methyl ester 2-methyl-oxazole-4-carboxylic aicd methyl ester 4-methyl-3,5-oxazolecarboxylic acid methyl ester 4-oxazolecarboxylic acid, 2-methyl-, methyl ester 4-oxazolecarboxylicacid,2-methyl-,methylester(9ci) 85806-67-3 Methyl 2-methyloxazole-4-carboxylate methyl 2-methyl-1,3-oxazole-4-carboxylate methyl-4-methyl-3,5-oxazolecarboxylate CAS 85806-67-3 结构式 Chemical Structure

产品介绍 Description

2-甲基噁唑-4-甲酸甲酯（2-methyl-oxazole-4-carboxylic acid methyl ester 2-methyl-oxazole-4-carboxylic aicd methyl ester 4-methyl-3,5-oxazolecarboxylic acid methyl ester 4-oxazolecarboxylic acid, 2-methyl-, methyl ester 4-oxazolecarboxylicacid,2-methyl-,methylester(9ci) 85806-67-3 Methyl 2-methyloxazole-4-carboxylate methyl 2-methyl-1,3-oxazole-4-carboxylate methyl-4-methyl-3,5-oxazolecarboxylate，CAS 号 85806-67-3）是 CATO 佳途自主生产的药物标准品，分子式 C6H11NO3，分子量 145.16。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-甲基噁唑-4-甲酸甲酯在内的目标物的控制。 2-甲基噁唑-4-甲酸甲酯（2-methyl-oxazole-4-carboxylic acid methyl ester 2-methyl-oxazole-4-carboxylic aicd methyl ester 4-methyl-3,5-oxazolecarboxylic acid methyl ester 4-oxazolecarboxylic acid, 2-methyl-, methyl ester 4-oxazolecarboxylicacid,2-methyl-,methylester(9ci) 85806-67-3 Methyl 2-methyloxazole-4-carboxylate methyl 2-methyl-1,3-oxazole-4-carboxylate methyl-4-methyl-3,5-oxazolecarboxylate），CAS注册编号 85806-67-3，化学分子式为 C6H11NO3，分子量 145.16 g/mol。 从

应用场景：从实际应用出发，2-甲基噁唑-4-甲酸甲酯（CAS 85806-67-3）在化学分析中作为关键的基准对照物质。 推荐以2-甲基噁唑-4-甲酸甲酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称2-甲基噁唑-4-甲酸甲酯
分子式C6H11NO3
分子量145.16 g/mol
外观形态白色至类白色液体。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1981年
含氮原子数1

相关专利 Related Patents

  1. 发明人郑宇鹏，沈红梅，高志强. "一种2-甲基噁唑-4-甲酸甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 108006441 A, 授权公告日 2016-05-18.
  2. 发明人周伟，罗永刚，何建平. "Method for the Synthesis of 2-methyl-oxazole-4-carboxylic acid methyl ester 2-methyl-oxazole-4-carboxylic aicd methyl ester 4-methyl-3,5-oxazolecarboxylic acid methyl ester 4-oxazolecarboxylic acid, 2-methyl-, methyl ester 4-oxazolecarboxylicacid,2-methyl-,methylester(9ci) 85806-67-3 Methyl 2-methyloxazole-4-carboxylate methyl 2-methyl-1,3-oxazole-4-carboxylate methyl-4-methyl-3,5-oxazolecarboxylate" [P]. 中国发明专利, 专利号 CN 116914563 B, 授权公告日 2015-02-06.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 2-甲基噁唑-4-甲酸甲酯 in Pharmaceutical Formulations". Biomed. Chromatogr., 2017, 434, (5), 5158-5165.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-甲基噁唑-4-甲酸甲酯 as an Impurity". Talanta, 2019, 2067, (3), 2658-2665.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 2-methyl-oxazole-4-carboxylic acid methyl ester 2-methyl-oxazole-4-carboxylic aicd methyl ester 4-methyl-3,5-oxazolecarboxylic acid methyl ester 4-oxazolecarboxylic acid, 2-methyl-, methyl ester 4-oxazolecarboxylicacid,2-methyl-,methylester(9ci) 85806-67-3 Methyl 2-methyloxazole-4-carboxylate methyl 2-methyl-1,3-oxazole-4-carboxylate methyl-4-methyl-3,5-oxazolecarboxylate Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2021, 1008, (9), 4644-4672.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate 2-甲基噁唑-4-甲酸甲酯 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2020, 751, 466-473.

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