BIT CAS 85951-65-1
2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyanate
| CAS 号 | 85951-65-1 |
| 分子式 | C23H42N4OS |
| 分子量 | 422.67 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
BIT（英文名 2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyanate，CAS 85951-65-1）属于药物标准品。分子式 C23H42N4OS，分子量 422.67。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C23H42N4OS 的BIT（2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-(4-ethoxyphenyl)methyl-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-(4-ethoxyphenyl)methyl-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyana
应用场景：针对化学分析用途，BIT（2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2- (4-ethoxyphenyl)methyl -n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2- (4-ethoxyphenyl)methyl -n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, eto
理化性质 Physical & Chemical Properties
| 中文名称 | BIT |
| 分子式 | C23H42N4OS |
| 分子量 | 422.67 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1981年 |
| 含氮原子数 | 4 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人郭海燕，马晓峰，唐晓军. "一种BIT的合成方法" [P]. 中国发明专利, 专利号 CN 110413759 B, 授权公告日 2025-03-11.
- 发明人何建平，王建平，林芳. "Method for the Synthesis of 2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyanate" [P]. 中国发明专利, 专利号 CN 110749541 B, 授权公告日 2021-02-16.
- 发明人马晓峰，张德明，孙丽萍. "A Process for Preparing High-Purity 2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyanate" [P]. 中国发明专利, 专利号 CN 111821989 A, 授权公告日 2022-08-06.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of BIT in Pharmaceutical Formulations". Talanta, 2020, 2124, (2), 9959-9971.
- Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of BIT as an Impurity". Chemosphere, 2019, 128, 5791-5814.
- Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyanate Using HRMS and NMR". J. Pharm. Biomed. Anal., 2024, 367, (10), 6147-6166.
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