(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯 CAS 862499-50-1

(1S,4S,8S) Carreira DOLEFIN Ligand (1S,4S,8S)--5-Benzyl-8-methoxy-1,8-dimethyl-2-(2 inverted exclamation marka-methylpropyl)-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethyl-2-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene 862499-50-1

纯度 97%+现货药物标准品
CAS 号862499-50-1
分子式C22H36O
分子量316.52 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯 (1S,4S,8S) Carreira DOLEFIN Ligand (1S,4S,8S)--5-Benzyl-8-methoxy-1,8-dimethyl-2-(2 inverted exclamation marka-methylpropyl)-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethyl-2-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene 862499-50-1 CAS 862499-50-1 结构式 Chemical Structure

产品介绍 Description

CAS 862499-50-1 对应的(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯（(1S,4S,8S) Carreira DOLEFIN Ligand (1S,4S,8S)--5-Benzyl-8-methoxy-1,8-dimethyl-2-(2 inverted exclamation marka-methylpropyl)-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethyl-2-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene 862499-50-1）为 CATO 佳途药物标准品产品线成员。分子式 C22H36O，分子量 316.52。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 862499-50-1 对应的化合物(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环2.2.2辛-2,5-二烯（英文标识 (1S,4S,8S) Carreira DOLEFIN Ligand (1S,4S,8S)--5-Benzyl-8-methoxy-1,8-dimethyl-2-(2 inverted exclamation marka-methylpropyl)-bicyclo2.2.2octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethyl-2-bicyclo2.2.2octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo2.2.2octa-2,5-die

应用场景：从实际应用出发，(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环 2.2.2 辛-2,5-二烯（CAS 862499-50-1）在化学分析中作为关键的基准对照物质。 推荐以(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环 2.2.2 辛-2,5-二烯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30

理化性质 Physical & Chemical Properties

中文名称(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯
分子式C22H36O
分子量316.52 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年

相关专利 Related Patents

  1. 发明人杨光，郑宇鹏，冯建国. "一种(1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯的合成方法" [P]. 中国发明专利, 专利号 CN 109279899 B, 授权公告日 2022-12-15.
  2. 发明人冯建国，罗永刚，唐晓军. "Method for the Synthesis of (1S,4S,8S) Carreira DOLEFIN Ligand (1S,4S,8S)--5-Benzyl-8-methoxy-1,8-dimethyl-2-(2 inverted exclamation marka-methylpropyl)-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethyl-2-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene 862499-50-1" [P]. 中国发明专利, 专利号 CN 112448987 B, 授权公告日 2015-12-01.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of (1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯 in Pharmaceutical Formulations". Biomed. Chromatogr., 2011, 1843, (11), 3820-3833.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯 as an Impurity". J. Chromatogr. A, 2023, 978, (2), 4718-4748.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of (1S,4S,8S) Carreira DOLEFIN Ligand (1S,4S,8S)--5-Benzyl-8-methoxy-1,8-dimethyl-2-(2 inverted exclamation marka-methylpropyl)-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethyl-2-bicyclo[2.2.2]octa-2,5-diene (1S,4S,8S)-5-Benzyl-2-isobutyl-8-methoxy-1,8-dimethylbicyclo[2.2.2]octa-2,5-diene 862499-50-1 Using HRMS and NMR". Anal. Methods, 2021, 405, (9), 1253-1263.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate (1<I>S</I>,4<I>S</I>,8<I>S</I>)-5-苄基-8-甲氧基-1,8-二甲基-2-(2′-甲基丙基)-双环[2.2.2]辛-2,5-二烯 Profile in Drug Substances According to ICH Guidelines". Talanta, 2012, 2014, (11), 875-886.

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