5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione CAS 863785-65-3

5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione

纯度 97%+现货药物标准品
CAS 号863785-65-3
分子式C12H10Cl2N2O4
分子量317.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione CAS 863785-65-3 结构式 Chemical Structure

产品介绍 Description

5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione（英文名 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione，CAS 863785-65-3）属于药物标准品。分子式 C12H10Cl2N2O4，分子量 317.12。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在质量保证方面，5-{(2,6-dichloropyridin-4-yl)aminomethylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 863785-65-3 对应的化合物5-{(2,6-dichloropyridin-4-yl)aminomethylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione（英文标识 5-{(2,6-dichloropyridin-4-yl)aminomethylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione），化学式 C12H10Cl2N2O4，相对分子质量 317.12。 从化学结构特征来看，5-{(2,6-dichloropyridin-4-yl)a

应用场景：针对化学分析用途，5-{ (2,6-dichloropyridin-4-yl)amino methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione（5-{ (2,6-dichloropyridin-4-yl)amino methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione）是具有明确定量溯源的认证级对照品。 推荐以5-{ (2,6-dichloropyridin-4-yl)amino methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione配制标准系列工作溶液，用于建立标准曲

理化性质 Physical & Chemical Properties

中文名称5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione
分子式C12H10Cl2N2O4
分子量317.12 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. Martínez F, Björnsson E, Jørgensen K. "一种5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione的合成方法" [P]. European Patent, EP 3286013 A1, 2018-10-24.
  2. 发明人刘建华，林芳，胡光. "Method for the Synthesis of 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione" [P]. 中国发明专利, 专利号 CN 112836078 A, 授权公告日 2021-09-07.
  3. 发明人李文辉，冯建国，郭海燕. "A Process for Preparing High-Purity 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione" [P]. 中国发明专利, 专利号 CN 114403954 A, 授权公告日 2022-09-17.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione in Pharmaceutical Formulations". Chemosphere, 2015, 886, 4683-4704.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione as an Impurity". Biomed. Chromatogr., 2018, 337, 5345-5350.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 5-{[(2,6-dichloropyridin-4-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione Using HRMS and NMR". J. Nat. Prod., 2020, 585, (4), 3819-3826.

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