(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether CAS 864466-71-7

(S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine 864466-71-7

纯度 97%+现货药物标准品
CAS 号864466-71-7
分子式C23H45NOSi
分子量379.70 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine 864466-71-7 CAS 864466-71-7 结构式 Chemical Structure

产品介绍 Description

CAS 864466-71-7 对应的(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether（(S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine 864466-71-7）为 CATO 佳途药物标准品产品线成员。分子式 C23H45NOSi，分子量 379.70。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

作为认证标准物质（CRM），(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 864466-71-7 对应的化合物(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether（英文标识 (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-(tert-Butyldimethylsiloxy)diphenylmethylpyrr

应用场景：从实际应用出发，(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether（CAS 864466-71-7）在化学分析中作为关键的基准对照物质。 推荐以(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： -

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether
分子式C23H45NOSi
分子量379.70 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1987年
含氮原子数1

相关专利 Related Patents

  1. 发明人唐晓军，郭海燕，林芳. "一种(<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether的合成方法" [P]. 中国发明专利, 专利号 CN 112691831 A, 授权公告日 2018-03-28.
  2. 发明人林芳，朱建伟，刘建华. "Method for the Synthesis of (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine 864466-71-7" [P]. 中国发明专利, 专利号 CN 110175806 A, 授权公告日 2016-03-28.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether in Pharmaceutical Formulations". Anal. Methods, 2020, 1439, 7189-7210.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol <I>tert</I>-butyldimethylsilyl ether as an Impurity". Chemosphere, 2024, 199, 2663-2680.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (S)-(-)-|A,|A-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (S)-(-)-|A,|A-Diphenylprolinol tert-butyldimethylsilyl ether (S)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine 864466-71-7 Using HRMS and NMR". Chromatographia, 2021, 2265, 5-16.

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