CAS 86496-18-6

2-Amino-5-[[[(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl]amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride [1S-(1|A,4|A,5|A)]-2-Amino-5-[[(4,5-dihydroxy-2-cyclopenten-1-yl)amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride

纯度 97%+现货药物标准品
CAS 号86496-18-6
分子式C12H15N5O3 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-Amino-5-[[[(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl]amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride [1S-(1|A,4|A,5|A)]-2-Amino-5-[[(4,5-dihydroxy-2-cyclopenten-1-yl)amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride CAS 86496-18-6 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（2-Amino-5-[[[(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl]amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride [1S-(1|A,4|A,5|A)]-2-Amino-5-[[(4,5-dihydroxy-2-cyclopenten-1-yl)amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride，CAS 86496-18-6），分子式 C12H15N5O3 2*HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

（2-Amino-5-(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-ylaminomethyl-1,7-dihydro-4H-pyrrolo2,3-dpyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride 1S-(1|A,4|A,5|A)-2-Amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl)aminomethyl-1,7-dihydro-4H-pyrrolo2,3-dpyrimidin-4-one Dihydrochloride），CAS注册编号 86496-18-6，化学分子式为 C12H15N5O3 2HCl，分子量 313.74 g/mol。 （C12H15N5O3 2HCl）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在U

应用场景：（2-Amino-5- (1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl amino methyl -1,7-dihydro-4H-pyrrolo 2,3-d pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride 1S-(1|A,4|A,5|A) -2-Amino-5- (4,5-dihydroxy-2-cyclopenten-1-yl)amino methyl -1,7-dihydro-4H-pyrrolo 2,3-d pyrimidin-4-one Dihydroc

理化性质 Physical & Chemical Properties

中文名称
分子式C12H15N5O3 2*HCl
分子量313.74 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1981年
卤素含量Cl取代
含氮原子数5

相关专利 Related Patents

  1. 发明人何建平，赵玉洁，罗永刚. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 110515401 A, 授权公告日 2020-08-02.
  2. 发明人李文辉，钱学锋，王建平. "Method for the Synthesis of 2-Amino-5-[[[(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl]amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride [1S-(1|A,4|A,5|A)]-2-Amino-5-[[(4,5-dihydroxy-2-cyclopenten-1-yl)amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride" [P]. 中国发明专利, 专利号 CN 114203016 B, 授权公告日 2021-04-18.
  3. 发明人陈志强，罗永刚，马晓峰. "A Process for Preparing High-Purity 2-Amino-5-[[[(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl]amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride [1S-(1|A,4|A,5|A)]-2-Amino-5-[[(4,5-dihydroxy-2-cyclopenten-1-yl)amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride" [P]. 中国发明专利, 专利号 CN 112327884 A, 授权公告日 2021-06-28.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Environ. Sci. Technol., 2013, 2319, 3972-3989.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Chemosphere, 2018, 1242, (12), 7579-7600.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 2-Amino-5-[[[(1S,4S,5R)-4,5-dihydroxy-2-cyclopenten-1-yl]amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride 86496-18-6 Queuine Dihydrochloride [1S-(1|A,4|A,5|A)]-2-Amino-5-[[(4,5-dihydroxy-2-cyclopenten-1-yl)amino]methyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one Dihydrochloride Using HRMS and NMR". Sci. Total Environ., 2019, 136, (6), 4927-4940.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2018, 500, 9254-9260.

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