7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy CAS 869311-26-2

7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy

纯度 97%+现货药物标准品
CAS 号869311-26-2
分子式C58H93ClN4O18
分子量1169.83 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy 7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy CAS 869311-26-2 结构式 Chemical Structure

产品介绍 Description

CAS 869311-26-2 对应的7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy（7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy）为 CATO 佳途药物标准品产品线成员。分子式 C58H93ClN4O18，分子量 1169.83。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy（7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-et

应用场景：从实际应用出发，7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy（CAS 869311-26-2）在化学分析中作为关键的基准对照物质。 推荐

理化性质 Physical & Chemical Properties

中文名称7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro
分子式C58H93ClN4O18
分子量1169.83 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）14.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. Davis P L, Anderson J P, Park J H. "一种7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy的合成方法" [P]. US Patent, US 10699192 B2, 2019-11-16.
  2. 发明人周伟，郑宇鹏，徐明华. "Method for the Synthesis of 7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy" [P]. 中国发明专利, 专利号 CN 111832528 B, 授权公告日 2019-12-24.
  3. 发明人徐明华，陈志强，韩伟. "A Process for Preparing High-Purity 7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy" [P]. 中国发明专利, 专利号 CN 116725842 A, 授权公告日 2015-07-17.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy in Pharmaceutical Formulations". J. Agric. Food Chem., 2025, 1794, 3047-3068.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-chloro-1-cyclopropyl-6-((2-(2-(3-(((2S,3S,4R,6R)-6-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacy as an Impurity". Sci. Total Environ., 2020, 407, 955-972.

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