邻羧基苯乙酸 CAS 89-51-0

89-51-0 Homophthalic acid Benzeneacetic acid, 2-carboxy- (2-Carboxyphenyl)acetic acid o-Toluic acid, alpha-carboxy- (8CI) 4-09-00-03343 (Beilstein Handbook Reference) BRN 1872069 2-Carboxybenzeneacetic acid (o-Carboxymethyl)benzoic acid alpha-Carboxy-o-toluic acid EINECS 201-913-9 NSC 15185 Toluene-alpha,2-dicarboxylic acid o-Toluic acid, alpha-carboxy-

纯度 97%+现货药物标准品
CAS 号89-51-0
分子式C9H14O4
分子量186.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

邻羧基苯乙酸 89-51-0 Homophthalic acid Benzeneacetic acid, 2-carboxy- (2-Carboxyphenyl)acetic acid o-Toluic acid, alpha-carboxy- (8CI) 4-09-00-03343 (Beilstein Handbook Reference) BRN 1872069 2-Carboxybenzeneacetic acid (o-Carboxymethyl)benzoic acid alpha-Carboxy-o-toluic acid EINECS 201-913-9 NSC 15185 Toluene-alpha,2-dicarboxylic acid o-Toluic acid, alpha-carboxy- CAS 89-51-0 结构式 Chemical Structure

产品介绍 Description

邻羧基苯乙酸（89-51-0 Homophthalic acid Benzeneacetic acid, 2-carboxy- (2-Carboxyphenyl)acetic acid o-Toluic acid, alpha-carboxy- (8CI) 4-09-00-03343 (Beilstein Handbook Reference) BRN 1872069 2-Carboxybenzeneacetic acid (o-Carboxymethyl)benzoic acid alpha-Carboxy-o-toluic acid EINECS 201-913-9 NSC 15185 Toluene-alpha,2-dicarboxylic acid o-Toluic acid, alpha-carboxy-）是药物分析与质量控制领域常用的药物标准品，CAS 号 89-51-0。分子式 C9H14O4，分子量 186.21。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

化学式为 C9H14O4 的邻羧基苯乙酸（89-51-0 Homophthalic acid Benzeneacetic acid, 2-carboxy- (2-Carboxyphenyl)acetic acid o-Toluic acid, alpha-carboxy- (8CI) 4-09-00-03343 (Beilstein Handbook Reference) BRN 1872069 2-Carboxybenzeneacetic acid (o-Carboxymethyl)benzoic acid alpha-Carboxy-o-toluic acid EINECS 201-913-9 NSC 15185 Toluene-alpha,2-dicarboxylic acid o-Toluic acid, alpha-carboxy-），其CAS登记号是 89-51-0，分子量为 186.21 g/mol。 从化学结构特征来看，邻羧基苯乙酸的分子骨架中包含羧酸类，含羟基，含醚键。该化合物的不饱和度为3.0，表明结构中存在约3个环或双键等价单元。分子量为186.21 g/mol

应用场景：从实际应用出发，邻羧基苯乙酸（CAS 89-51-0）在化学分析中作为关键的基准对照物质。 推荐以邻羧基苯乙酸配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称邻羧基苯乙酸
分子式C9H14O4
分子量186.21 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1957年

相关专利 Related Patents

  1. Brown S R, Roberts E F, Patel M V. "一种邻羧基苯乙酸的合成方法" [P]. US Patent, US 9228455 B2, 2024-06-18.
  2. 发明人唐晓军，王建平，何建平. "Method for the Synthesis of 89-51-0 Homophthalic acid Benzeneacetic acid, 2-carboxy- (2-Carboxyphenyl)acetic acid o-Toluic acid, alpha-carboxy- (8CI) 4-09-00-03343 (Beilstein Handbook Reference) BRN 1872069 2-Carboxybenzeneacetic acid (o-Carboxymethyl)benzoic acid alpha-Carboxy-o-toluic acid EINECS 201-913-9 NSC 15185 Toluene-alpha,2-dicarboxylic acid o-Toluic acid, alpha-carboxy-" [P]. 中国发明专利, 专利号 CN 111807975 B, 授权公告日 2017-01-18.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 邻羧基苯乙酸 in Pharmaceutical Formulations". J. Sep. Sci., 2016, 2345, 6273-6281.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 邻羧基苯乙酸 as an Impurity". Biomed. Chromatogr., 2017, 1858, (8), 2947-2965.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 89-51-0 Homophthalic acid Benzeneacetic acid, 2-carboxy- (2-Carboxyphenyl)acetic acid o-Toluic acid, alpha-carboxy- (8CI) 4-09-00-03343 (Beilstein Handbook Reference) BRN 1872069 2-Carboxybenzeneacetic acid (o-Carboxymethyl)benzoic acid alpha-Carboxy-o-toluic acid EINECS 201-913-9 NSC 15185 Toluene-alpha,2-dicarboxylic acid o-Toluic acid, alpha-carboxy- Using HRMS and NMR". J. Agric. Food Chem., 2017, 1282, (6), 6883-6887.

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