5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶 CAS 894086-00-1

5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE;5-[BIS(TERT-BUTYL)PHOSPHINO]-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;BIPPYPHOS;T-BU-BIPPYPHOS SC11191

纯度 97%+现货药物标准品
CAS 号894086-00-1
分子式C32H61N4P
分子量532.83 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶 5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE;5-[BIS(TERT-BUTYL)PHOSPHINO]-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;BIPPYPHOS;T-BU-BIPPYPHOS SC11191 CAS 894086-00-1 结构式 Chemical Structure

产品介绍 Description

5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶（5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE;5-[BIS(TERT-BUTYL)PHOSPHINO]-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;BIPPYPHOS;T-BU-BIPPYPHOS SC11191，CAS 号 894086-00-1）是 CATO 佳途自主生产的药物标准品，分子式 C32H61N4P，分子量 532.83。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-1,4′ 联吡啶的产生途径与其化学式中含氮杂环结构，含氰基，有机磷密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C32H61N4P 的5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-1,4′ 联吡啶（5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4'BIPYRAZOLE;5-BIS(TERT-BUTYL)PHOSPHINO-1',3',5'-TRIPHEN

应用场景：5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>- 1,4′ 联吡啶（5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHEN

理化性质 Physical & Chemical Properties

中文名称5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶
分子式C32H61N4P
分子量532.83 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数4

相关专利 Related Patents

  1. 发明人胡光，林芳，赵玉洁. "一种5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶的合成方法" [P]. 中国发明专利, 专利号 CN 110911453 B, 授权公告日 2021-10-28.
  2. 发明人郭海燕，李文辉，黄志刚. "Method for the Synthesis of 5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE;5-[BIS(TERT-BUTYL)PHOSPHINO]-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;BIPPYPHOS;T-BU-BIPPYPHOS SC11191" [P]. 中国发明专利, 专利号 CN 117833397 A, 授权公告日 2019-02-27.
  3. 发明人马晓峰，郭海燕，钱学锋. "A Process for Preparing High-Purity 5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE;5-[BIS(TERT-BUTYL)PHOSPHINO]-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;BIPPYPHOS;T-BU-BIPPYPHOS SC11191" [P]. 中国发明专利, 专利号 CN 110697772 A, 授权公告日 2021-08-28.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2019, 1031, 8812-8816.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-（二-<I> 叔</I>丁基膦）-1′,3′,5′-三苯基-1′<I>H</I>-[1,4′] 联吡啶 as an Impurity". J. Chromatogr. A, 2021, 1106, 5007-5011.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 5-(Di-t-butylphosphino)-1',3',5'-triphenyl-1,4'-bi-1H-pyrazole 894086-00-1 5-(DI-T-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-1,4-BIPYRAZOLE;5-(DI-TERT-BUTYLPHOSPHINO)-1',3',5'-TRIPHENYL-1'H-[1,4']BIPYRAZOLE;5-[BIS(TERT-BUTYL)PHOSPHINO]-1',3',5'-TRIPHENYL-1,4'-BI-1H-PYRAZOLE;BIPPYPHOS;T-BU-BIPPYPHOS SC11191 Using HRMS and NMR". Sci. Total Environ., 2022, 1429, (1), 4777-4785.

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