(R)-(-)-2-羟基-4-苯基丁酸乙酯 CAS 90315-82-5
Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy-4-phenylbutyrate (r)-ethyl 2-hydroxy-4-phenylbutanoate r-2-hydroxy-4-phenyl butyric acid ethyl ester (r)-2-hydroxy-4-phenylbutyrate (r)-ethyl-4-phenyl-2-hydroxybutyrate ethyl(r)-2-hydroxy-4-phenylbutyrate ethyl-(r)-(-)-2-hydroxy 4-phenylbutyrate (r)-2-hydroxy-4-phenylbutanoic acid ethyl ester (r)-ethyl-2-hydroxy-4-phenylbutyrate ethyl(r)-2-hydroxy-4-phenylbutanoate (r)-ethyl 2-hydroxy-4-phenylbutanate 90315-82-5
| CAS 号 | 90315-82-5 |
| 分子式 | C12H22O3 |
| 分子量 | 214.30 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
(R)-(-)-2-羟基-4-苯基丁酸乙酯（英文名 Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy-4-phenylbutyrate (r)-ethyl 2-hydroxy-4-phenylbutanoate r-2-hydroxy-4-phenyl butyric acid ethyl ester (r)-2-hydroxy-4-phenylbutyrate (r)-ethyl-4-phenyl-2-hydroxybutyrate ethyl(r)-2-hydroxy-4-phenylbutyrate ethyl-(r)-(-)-2-hydroxy 4-phenylbutyrate (r)-2-hydroxy-4-phenylbutanoic acid ethyl ester (r)-ethyl-2-hydroxy-4-phenylbutyrate ethyl(r)-2-hydroxy-4-phenylbutanoate (r)-ethyl 2-hydroxy-4-phenylbutanate 90315-82-5，CAS 90315-82-5）属于药物标准品。分子式 C12H22O3，分子量 214.30。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 (R)-(-)-2-羟基-4-苯基丁酸乙酯（Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy-4-phenylbutyrate (r)-ethyl 2-hydroxy-
应用场景：(R)-(-)-2-羟基-4-苯基丁酸乙酯（Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy
理化性质 Physical & Chemical Properties
| 中文名称 | (R)-(-)-2-羟基-4-苯基丁酸乙酯 |
| 分子式 | C12H22O3 |
| 分子量 | 214.30 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1982年 |
相关专利 Related Patents
- 发明人徐明华，高志强，唐晓军. "一种(R)-(-)-2-羟基-4-苯基丁酸乙酯的合成方法" [P]. 中国发明专利, 专利号 CN 109984607 B, 授权公告日 2018-05-28.
- 发明人钱学锋，胡光，罗永刚. "Method for the Synthesis of Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy-4-phenylbutyrate (r)-ethyl 2-hydroxy-4-phenylbutanoate r-2-hydroxy-4-phenyl butyric acid ethyl ester (r)-2-hydroxy-4-phenylbutyrate (r)-ethyl-4-phenyl-2-hydroxybutyrate ethyl(r)-2-hydroxy-4-phenylbutyrate ethyl-(r)-(-)-2-hydroxy 4-phenylbutyrate (r)-2-hydroxy-4-phenylbutanoic acid ethyl ester (r)-ethyl-2-hydroxy-4-phenylbutyrate ethyl(r)-2-hydroxy-4-phenylbutanoate (r)-ethyl 2-hydroxy-4-phenylbutanate 90315-82-5" [P]. 中国发明专利, 专利号 CN 111306538 A, 授权公告日 2018-03-18.
- 发明人郭海燕，孙丽萍，杨光. "A Process for Preparing High-Purity Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy-4-phenylbutyrate (r)-ethyl 2-hydroxy-4-phenylbutanoate r-2-hydroxy-4-phenyl butyric acid ethyl ester (r)-2-hydroxy-4-phenylbutyrate (r)-ethyl-4-phenyl-2-hydroxybutyrate ethyl(r)-2-hydroxy-4-phenylbutyrate ethyl-(r)-(-)-2-hydroxy 4-phenylbutyrate (r)-2-hydroxy-4-phenylbutanoic acid ethyl ester (r)-ethyl-2-hydroxy-4-phenylbutyrate ethyl(r)-2-hydroxy-4-phenylbutanoate (r)-ethyl 2-hydroxy-4-phenylbutanate 90315-82-5" [P]. 中国发明专利, 专利号 CN 112508610 A, 授权公告日 2020-10-22.
参考文献 Literature
- Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of (R)-(-)-2-羟基-4-苯基丁酸乙酯 in Pharmaceutical Formulations". Chemosphere, 2019, 1748, 7823-7834.
- Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (R)-(-)-2-羟基-4-苯基丁酸乙酯 as an Impurity". Biomed. Chromatogr., 2025, 460, (6), 2238-2255.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of Ethyl (R)-(-)-2-Hydroxy-4-phenylbutyrate (r)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyric acid ethyl ester (r)-(-)-2-hydroxy-4-phenylbutyrate ethyl ester r(-) ethyl-2-hydroxy-4-phenylbutyrate ethyl (r)-2-hydroxy-4-phenylbutyrate ethyl(r)2-hydroxy-4-phenylbutyrate (r)-ethyl 2-hydroxy-4-phenylbutanoate r-2-hydroxy-4-phenyl butyric acid ethyl ester (r)-2-hydroxy-4-phenylbutyrate (r)-ethyl-4-phenyl-2-hydroxybutyrate ethyl(r)-2-hydroxy-4-phenylbutyrate ethyl-(r)-(-)-2-hydroxy 4-phenylbutyrate (r)-2-hydroxy-4-phenylbutanoic acid ethyl ester (r)-ethyl-2-hydroxy-4-phenylbutyrate ethyl(r)-2-hydroxy-4-phenylbutanoate (r)-ethyl 2-hydroxy-4-phenylbutanate 90315-82-5 Using HRMS and NMR". J. Agric. Food Chem., 2023, 1400, (12), 4953-4982.
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