聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端 CAS 9057-91-4
9057-91-4 KL 3 Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, polymer with 1,3-diisocyanatomethylbenzene Poly(oxy(methyl-2-ethane)), toluene diisocyanate polymer Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, 1,3-diisocyanatomethylbenzene polymer Polypropylene glycol, toluene diisocyanate polymer Polypropylene glycol, toluenediisocyanate polymer Polypropyleneoxydiols, toluenediisocyanate polymer Toluene diisocyanate, polypropylene glycol polymer Toluene diisocyanate, polypropylene glycol resin
| CAS 号 | 9057-91-4 |
| 分子式 | C9H12N2O2 C3H8O2 |
| 分子量 | N/A g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端（9057-91-4 KL 3 Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, polymer with 1,3-diisocyanatomethylbenzene Poly(oxy(methyl-2-ethane)), toluene diisocyanate polymer Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, 1,3-diisocyanatomethylbenzene polymer Polypropylene glycol, toluene diisocyanate polymer Polypropylene glycol, toluenediisocyanate polymer Polypropyleneoxydiols, toluenediisocyanate polymer Toluene diisocyanate, polypropylene glycol polymer Toluene diisocyanate, polypropylene glycol resin）是药物分析与质量控制领域常用的药物标准品，CAS 号 9057-91-4。分子式 C9H12N2O2 C3H8O2。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端的产生途径与其化学式中氨基酸衍生物，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H12N2O2 C3H8O2 的聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端（9057-91-4 KL 3 Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, polymer with 1,3-diisocyanatomethylbenzene Poly(oxy(methyl-2-ethane)), toluene diisocyanate polymer Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, 1,3-diisocyanatomethylbenzene polymer Polypropylene glycol, toluene diisocyanate polymer Polypropylene glycol, toluenediisocyan
应用场景：在化学分析实验室中，聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端（CAS 9057-91-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西
理化性质 Physical & Chemical Properties
| 中文名称 | 聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端 |
| 分子式 | C9H12N2O2 C3H8O2 |
| 分子量 | 256.30 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1959年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- Johnson M A, Lee S K, Patel M V. "一种聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端的合成方法" [P]. US Patent, US 9942932 B2, 2024-09-18.
- 发明人孙丽萍，张德明，徐明华. "Method for the Synthesis of 9057-91-4 KL 3 Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, polymer with 1,3-diisocyanatomethylbenzene Poly(oxy(methyl-2-ethane)), toluene diisocyanate polymer Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, 1,3-diisocyanatomethylbenzene polymer Polypropylene glycol, toluene diisocyanate polymer Polypropylene glycol, toluenediisocyanate polymer Polypropyleneoxydiols, toluenediisocyanate polymer Toluene diisocyanate, polypropylene glycol polymer Toluene diisocyanate, polypropylene glycol resin" [P]. 中国发明专利, 专利号 CN 115671128 A, 授权公告日 2015-06-10.
- Schröder R, Rossi M, Lefèvre J P. "A Process for Preparing High-Purity 9057-91-4 KL 3 Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, polymer with 1,3-diisocyanatomethylbenzene Poly(oxy(methyl-2-ethane)), toluene diisocyanate polymer Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, 1,3-diisocyanatomethylbenzene polymer Polypropylene glycol, toluene diisocyanate polymer Polypropylene glycol, toluenediisocyanate polymer Polypropyleneoxydiols, toluenediisocyanate polymer Toluene diisocyanate, polypropylene glycol polymer Toluene diisocyanate, polypropylene glycol resin" [P]. European Patent, EP 3302267 A1, 2022-09-16.
参考文献 Literature
- Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端 in Pharmaceutical Formulations". Biomed. Chromatogr., 2021, 1667, (2), 9422-9442.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 聚(丙二醇)，甲苯基-2,4-二异氰酸酯封端 as an Impurity". Molecules, 2019, 1867, (11), 8053-8081.
- Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 9057-91-4 KL 3 Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, polymer with 1,3-diisocyanatomethylbenzene Poly(oxy(methyl-2-ethane)), toluene diisocyanate polymer Poly(oxy(methyl-1,2-ethanediyl)), alpha-hydro-omega-hydroxy-, 1,3-diisocyanatomethylbenzene polymer Polypropylene glycol, toluene diisocyanate polymer Polypropylene glycol, toluenediisocyanate polymer Polypropyleneoxydiols, toluenediisocyanate polymer Toluene diisocyanate, polypropylene glycol polymer Toluene diisocyanate, polypropylene glycol resin Using HRMS and NMR". Food Chem., 2018, 1385, 8172-8177.
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