<I>N</I>-Boc-4-氰基哌啶 CAS 91419-52-2
1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperidine-1-carboxylate 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester tert-Butyl 4-cyanopiperidine-1-carboxylate 91419-52-2
| CAS 号 | 91419-52-2 |
| 分子式 | C11H18N2O2 |
| 分子量 | 210.27 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
<I>N</I>-Boc-4-氰基哌啶（英文名 1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperidine-1-carboxylate 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester tert-Butyl 4-cyanopiperidine-1-carboxylate 91419-52-2，CAS 91419-52-2）属于药物标准品。分子式 C11H18N2O2，分子量 210.27。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 91419-52-2 对应的化合物<I>N</I>-Boc-4-氰基哌啶（英文标识 1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperidine-1-carboxylate 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic ac
应用场景：针对化学分析用途，<I>N</I>-Boc-4-氰基哌啶（1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperid
理化性质 Physical & Chemical Properties
| 中文名称 | <I>N</I>-Boc-4-氰基哌啶 |
| 分子式 | C11H18N2O2 |
| 分子量 | 210.27 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1983年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人罗永刚，钱学锋，高志强. "一种<I>N</I>-Boc-4-氰基哌啶的合成方法" [P]. 中国发明专利, 专利号 CN 114305901 A, 授权公告日 2015-08-06.
- 发明人刘建华，高志强，朱建伟. "Method for the Synthesis of 1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperidine-1-carboxylate 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester tert-Butyl 4-cyanopiperidine-1-carboxylate 91419-52-2" [P]. 中国发明专利, 专利号 CN 110487829 A, 授权公告日 2022-06-05.
- 发明人何建平，冯建国，胡光. "A Process for Preparing High-Purity 1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperidine-1-carboxylate 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester tert-Butyl 4-cyanopiperidine-1-carboxylate 91419-52-2" [P]. 中国发明专利, 专利号 CN 112981148 B, 授权公告日 2020-02-23.
参考文献 Literature
- Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>-Boc-4-氰基哌啶 in Pharmaceutical Formulations". Molecules, 2021, 327, (10), 3647-3661.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>-Boc-4-氰基哌啶 as an Impurity". Anal. Methods, 2013, 361, (10), 1765-1778.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 1-N-Boc-4-cyanopiperidine 4-cyano-piperidine-1-carboxylic acid tert-butyl ester 1-n-boc-piperidine-4-carbonitrile 1-n-boc-4-cyano-piperidine n-boc-4-cyanopiperidine 1-boc-4-cyanopiperidine n-boc-piperidine-4-carbonitrile n-boc-4-cyano-piperidine tert-butyl-4-cyanopiperidine-1-carboxylate 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester tert-Butyl 4-cyanopiperidine-1-carboxylate 91419-52-2 Using HRMS and NMR". Anal. Chem., 2022, 115, 1581-1604.
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