甲苯胺蓝O CAS 92-31-9
92-31-9 15XUH0X66N Tolonium chloride Tolonium chloride [INN] C.I. Basic Blue 17 3-Amino-7-dimethylamino-2-methylphenazathionium Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1) C.I. 925 F Klot 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride Basic Blue 17 Blutene Blutene chloride CCRIS 4933 Chlorure de tolonium [INN-French] Cloruro de tolonio [INN-Spanish] Dimethyltoluthionine chloride Dimethyltoluthionine chloride (VAN) EINECS 202-146-2 Gabilin Klot Menodin Modr Toluidinova [Czech] Modr Zasadita 17 [Czech] NSC 11225 Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Schultz 1041 Schultz no. 1041 Tolazul Toloni chloridum Tolonii chloridum [INN-Latin] Tolonium Toluidene Blue O Chloride Toluidinblau [German] Toluidine Blue Toluidine Blue O Toluidine Blue OO Toluidine Blue (phenothiazine dye) Chlorure de tolonium Cloruro de tolonio Modr Toluidinova Modr Zasadita 17 Tolonii chloridum Toluidinblau UNII-15XUH0X66N
| CAS 号 | 92-31-9 |
| 分子式 | C15H22N3S Cl |
| 分子量 | N/A g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
甲苯胺蓝O（92-31-9 15XUH0X66N Tolonium chloride Tolonium chloride [INN] C.I. Basic Blue 17 3-Amino-7-dimethylamino-2-methylphenazathionium Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1) C.I. 925 F Klot 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride Basic Blue 17 Blutene Blutene chloride CCRIS 4933 Chlorure de tolonium [INN-French] Cloruro de tolonio [INN-Spanish] Dimethyltoluthionine chloride Dimethyltoluthionine chloride (VAN) EINECS 202-146-2 Gabilin Klot Menodin Modr Toluidinova [Czech] Modr Zasadita 17 [Czech] NSC 11225 Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Schultz 1041 Schultz no. 1041 Tolazul Toloni chloridum Tolonii chloridum [INN-Latin] Tolonium Toluidene Blue O Chloride Toluidinblau [German] Toluidine Blue Toluidine Blue O Toluidine Blue OO Toluidine Blue (phenothiazine dye) Chlorure de tolonium Cloruro de tolonio Modr Toluidinova Modr Zasadita 17 Tolonii chloridum Toluidinblau UNII-15XUH0X66N）是药物分析与质量控制领域常用的药物标准品，CAS 号 92-31-9。分子式 C15H22N3S Cl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
与同类药物标准品相比，甲苯胺蓝O的分子量为311.87 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 92-31-9 对应的化合物甲苯胺蓝O（英文标识 92-31-9 15XUH0X66N Tolonium chloride Tolonium chloride INN C.I. Basic Blue 17 3-Amino-7-dimethylamino-2-methylphenazathionium Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1) C.I. 925 F Klot 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride Basic Blue 17 Blutene Blutene chloride CCRIS 4933 Chlorure de
应用场景：在化学分析实验室中，甲苯胺蓝O（CAS 92-31-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以甲苯胺蓝O配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 甲苯胺蓝O |
| 分子式 | C15H22N3S Cl |
| 分子量 | 311.87 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | Cl取代 |
| 含氮原子数 | 3 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人李文辉，郭海燕，何建平. "一种甲苯胺蓝O的合成方法" [P]. 中国发明专利, 专利号 CN 115941895 A, 授权公告日 2017-08-23.
- 发明人赵玉洁，张德明，杨光. "Method for the Synthesis of 92-31-9 15XUH0X66N Tolonium chloride Tolonium chloride [INN] C.I. Basic Blue 17 3-Amino-7-dimethylamino-2-methylphenazathionium Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1) C.I. 925 F Klot 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride Basic Blue 17 Blutene Blutene chloride CCRIS 4933 Chlorure de tolonium [INN-French] Cloruro de tolonio [INN-Spanish] Dimethyltoluthionine chloride Dimethyltoluthionine chloride (VAN) EINECS 202-146-2 Gabilin Klot Menodin Modr Toluidinova [Czech] Modr Zasadita 17 [Czech] NSC 11225 Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Schultz 1041 Schultz no. 1041 Tolazul Toloni chloridum Tolonii chloridum [INN-Latin] Tolonium Toluidene Blue O Chloride Toluidinblau [German] Toluidine Blue Toluidine Blue O Toluidine Blue OO Toluidine Blue (phenothiazine dye) Chlorure de tolonium Cloruro de tolonio Modr Toluidinova Modr Zasadita 17 Tolonii chloridum Toluidinblau UNII-15XUH0X66N" [P]. 中国发明专利, 专利号 CN 114114599 A, 授权公告日 2024-11-14.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 甲苯胺蓝O in Pharmaceutical Formulations". J. Sep. Sci., 2025, 1118, 6699-6717.
- Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 甲苯胺蓝O as an Impurity". Environ. Sci. Technol., 2018, 285, 2575-2592.
- Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 92-31-9 15XUH0X66N Tolonium chloride Tolonium chloride [INN] C.I. Basic Blue 17 3-Amino-7-dimethylamino-2-methylphenazathionium Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1) C.I. 925 F Klot 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride Basic Blue 17 Blutene Blutene chloride CCRIS 4933 Chlorure de tolonium [INN-French] Cloruro de tolonio [INN-Spanish] Dimethyltoluthionine chloride Dimethyltoluthionine chloride (VAN) EINECS 202-146-2 Gabilin Klot Menodin Modr Toluidinova [Czech] Modr Zasadita 17 [Czech] NSC 11225 Phenazathionium, 3-amino-7-(dimethylamino)-2-methyl-, chloride Schultz 1041 Schultz no. 1041 Tolazul Toloni chloridum Tolonii chloridum [INN-Latin] Tolonium Toluidene Blue O Chloride Toluidinblau [German] Toluidine Blue Toluidine Blue O Toluidine Blue OO Toluidine Blue (phenothiazine dye) Chlorure de tolonium Cloruro de tolonio Modr Toluidinova Modr Zasadita 17 Tolonii chloridum Toluidinblau UNII-15XUH0X66N Using HRMS and NMR". J. Nat. Prod., 2018, 2210, 2016-2030.
- Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 甲苯胺蓝O Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2025, 492, 8550-8553.
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