5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride CAS 92223-95-5

5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride

纯度 97%+现货药物标准品
CAS 号92223-95-5
分子式C7H11N3 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride 5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride CAS 92223-95-5 结构式 Chemical Structure

产品介绍 Description

5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride（5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 92223-95-5。分子式 C7H11N3 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

化学式为 C7H11N3 2HCl 的5-Methyl-4,5,6,7-tetrahydro-3H-imidazo4,5-cpyridine dihydrochloride（5-Methyl-4,5,6,7-tetrahydro-3H-imidazo4,5-cpyridine dihydrochloride），其CAS登记号是 92223-95-5，分子量为 173.64 g/mol。 依据分子式为 C7H11N3 2HCl 的5-Methyl-4,5,6,7-tetrahydro-3H-imidazo4,5-cpyridine dihydrochloride结构特征，其分子内含含氰基，含氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 173.64 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考

应用场景：5-Methyl-4,5,6,7-tetrahydro-3H-imidazo 4,5-c pyridine dihydrochloride（5-Methyl-4,5,6,7-tetrahydro-3H-imidazo 4,5-c pyridine dihydrochloride，CAS 92223-95-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-Methyl-4,5,6,7-tetrahydro-3H-imidazo 4,5-c pyridine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检

理化性质 Physical & Chemical Properties

中文名称5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride
分子式C7H11N3 2*HCl
分子量173.64 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1983年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. Nielsen H, Martínez F, Lefèvre J P. "一种5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride的合成方法" [P]. European Patent, EP 3388562 A1, 2021-03-23.
  2. Mueller T, Chen K W, Kumar R. "Method for the Synthesis of 5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride" [P]. US Patent, US 11158738 B2, 2025-11-13.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2022, 1356, 6791-6818.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride as an Impurity". Chemosphere, 2010, 2388, (11), 9993-10003.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride Using HRMS and NMR". Environ. Sci. Technol., 2011, 2013, (12), 2948-2976.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 5-Methyl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2014, 2123, (7), 5526-5531.

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