5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol CAS 923124-24-7

5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol

纯度 97%+现货药物标准品
CAS 号923124-24-7
分子式C12H20N4OS
分子量268.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol CAS 923124-24-7 结构式 Chemical Structure

产品介绍 Description

5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol（5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol，CAS 号 923124-24-7）是 CATO 佳途自主生产的药物标准品，分子式 C12H20N4OS，分子量 268.38。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol在内的目标物的控制。 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol（5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol），CAS注册编号 923124-24-7，化学分子式为 C12H20N4OS，分子量 268.38 g/mol。 依据分子式为 C12H20N4OS 的5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol结构特征，其分子内含含氮杂环结构，酰胺类，含硫有机，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 268.38 g/mol 这一参数对质谱检测中的

应用场景：5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol（5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol，CAS 923124-24-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇

理化性质 Physical & Chemical Properties

中文名称5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
分子式C12H20N4OS
分子量268.38 g/mol
外观形态类白色至淡黄色低熔点固体。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人唐晓军，赵玉洁，马晓峰. "一种5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol的合成方法" [P]. 中国发明专利, 专利号 CN 116608120 B, 授权公告日 2019-02-20.
  2. Mueller T, Anderson J P, Chen K W. "Method for the Synthesis of 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol" [P]. US Patent, US 10494404 B2, 2024-02-08.
  3. O'Brien P Q, Kumar R, Schröder R. "A Process for Preparing High-Purity 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol" [P]. US Patent, US 10919732 B2, 2016-07-18.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in Pharmaceutical Formulations". Anal. Methods, 2013, 1430, (2), 9420-9437.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol as an Impurity". Chromatographia, 2016, 2166, (4), 2779-2803.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol Using HRMS and NMR". Biomed. Chromatogr., 2025, 1924, 1780-1801.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 5-piperidin-1-yl-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazole-3-thiol Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2019, 146, (8), 9329-9357.

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