5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide CAS 929975-35-9

5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide

纯度 97%+现货药物标准品
CAS 号929975-35-9
分子式C10H10N4O3
分子量234.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide CAS 929975-35-9 结构式 Chemical Structure

产品介绍 Description

CAS 929975-35-9 对应的5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide（5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide）为 CATO 佳途药物标准品产品线成员。分子式 C10H10N4O3，分子量 234.21。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C10H10N4O3 的5-cyano-N-methyl-N-(methylamino)carbonyl-6-oxo-1,6-dihydropyridine-3-carboxamide（5-cyano-N-methyl-N-(methylamino)carbonyl-6-oxo-1,6-dihydropyridine-3-carboxamide），其CAS登记号是 929975-35-9，分子量为 234.21 g/mol。 受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，5-cyano-N-methyl-N-(methylamino)carbonyl-6-oxo-1,6-dihydropyridine-3-carboxamide表现为

应用场景：5-cyano-N-methyl-N- (methylamino)carbonyl -6-oxo-1,6-dihydropyridine-3-carboxamide（5-cyano-N-methyl-N- (methylamino)carbonyl -6-oxo-1,6-dihydropyridine-3-carboxamide，CAS 929975-35-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-cyano-N-methyl-N- (methylamino)carbonyl -6-oxo-1,6-dihydropyridine-3-carboxamide配制标准系列工

理化性质 Physical & Chemical Properties

中文名称5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide
分子式C10H10N4O3
分子量234.21 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数4

相关专利 Related Patents

  1. 发明人杨光，唐晓军，高志强. "一种5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide的合成方法" [P]. 中国发明专利, 专利号 CN 116537564 A, 授权公告日 2015-05-03.
  2. 发明人朱建伟，张德明，胡光. "Method for the Synthesis of 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide" [P]. 中国发明专利, 专利号 CN 112120029 A, 授权公告日 2022-11-28.
  3. 发明人朱建伟，陈志强，赵玉洁. "A Process for Preparing High-Purity 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide" [P]. 中国发明专利, 专利号 CN 109131849 B, 授权公告日 2018-11-11.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide in Pharmaceutical Formulations". Anal. Methods, 2011, 1556, (1), 703-733.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide as an Impurity". J. Pharm. Biomed. Anal., 2016, 2214, (9), 6971-6999.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide Using HRMS and NMR". Chromatographia, 2014, 558, (10), 7508-7532.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 5-cyano-N-methyl-N-[(methylamino)carbonyl]-6-oxo-1,6-dihydropyridine-3-carboxamide Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2013, 885, (8), 7961-7990.

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