(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛 CAS 95715-87-0

95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form [MI] (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (+)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 3-Oxazolidinecarboxylic acid, 4-formyl-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-

纯度 97%+现货药物标准品
CAS 号95715-87-0
分子式C11H19NO4
分子量229.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛 95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form [MI] (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (+)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 3-Oxazolidinecarboxylic acid, 4-formyl-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)- CAS 95715-87-0 结构式 Chemical Structure

产品介绍 Description

(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛（95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form [MI] (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (+)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 3-Oxazolidinecarboxylic acid, 4-formyl-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-，CAS 号 95715-87-0）是 CATO 佳途自主生产的药物标准品，分子式 C11H19NO4，分子量 229.27。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在质量保证方面，(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C11H19NO4 的(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛（95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form MI (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-

应用场景：针对化学分析用途，(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛（95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form MI (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl

理化性质 Physical & Chemical Properties

中文名称(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛
分子式C11H19NO4
分子量229.27 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1984年
含氮原子数1

相关专利 Related Patents

  1. 发明人徐明华，黄志刚，张德明. "一种(<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛的合成方法" [P]. 中国发明专利, 专利号 CN 110453455 A, 授权公告日 2022-04-15.
  2. 发明人钱学锋，冯建国，周伟. "Method for the Synthesis of 95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form [MI] (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (+)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 3-Oxazolidinecarboxylic acid, 4-formyl-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)-" [P]. 中国发明专利, 专利号 CN 117419544 B, 授权公告日 2025-07-06.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛 in Pharmaceutical Formulations". Anal. Chem., 2021, 1455, 6585-6593.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛 as an Impurity". Chromatographia, 2013, 1504, (7), 6761-6765.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form [MI] (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (+)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 3-Oxazolidinecarboxylic acid, 4-formyl-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)- Using HRMS and NMR". Anal. Chim. Acta, 2011, 551, (11), 4189-4208.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate (<I>R</I>)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2011, 1902, 9572-9594.

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