Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH CAS 957310-66-6

产品介绍 Description

CAS 957310-66-6 对应的Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH（(2R)-1-tert-butoxycarbonyl-2-(4-tert-butylbenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-tert-butylphenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 957310-66-6 Boc-(R)-alpha-(4-tert-butylphenyl)-proline）为 CATO 佳途药物标准品产品线成员。分子式 C21H37NO4，分子量 367.52。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH（(2R)-1-tert-butoxycarbonyl-2-(4-tert-butylbenzyl)proline (2R)-1-tert-butoxycarbonyl-2-(4-tert-butylphenyl)methylpyrrolidine-2-carboxylic acid (2R)-2-(4-tert-butylphenyl)methyl-1-(2-methylpropan-2-yl)oxy-oxomethyl-2-pyrrolidinecarboxylic acid (2R)-2-(4-tert-butylphenyl)methyl-1-(2

应用场景：在化学分析实验室中，Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH（CAS 957310-66-6）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议

理化性质 Physical & Chemical Properties

相关专利 Related Patents

1. 发明人徐明华，何建平，赵玉洁. "一种Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH的合成方法" [P]. 中国发明专利, 专利号 CN 117581854 B, 授权公告日 2018-06-08.
2. 发明人孙丽萍，周伟，马晓峰. "Method for the Synthesis of (2R)-1-tert-butoxycarbonyl-2-(4-tert-butylbenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-tert-butylphenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 957310-66-6 Boc-(R)-alpha-(4-tert-butylphenyl)-proline" [P]. 中国发明专利, 专利号 CN 110009396 B, 授权公告日 2024-03-05.
3. 发明人周伟，王建平，高志强. "A Process for Preparing High-Purity (2R)-1-tert-butoxycarbonyl-2-(4-tert-butylbenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-tert-butylphenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 957310-66-6 Boc-(R)-alpha-(4-tert-butylphenyl)-proline" [P]. 中国发明专利, 专利号 CN 109279046 B, 授权公告日 2018-07-24.

参考文献 Literature

1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH in Pharmaceutical Formulations". J. Agric. Food Chem., 2013, 1585, (8), 3434-3455.
2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of Boc-(<I>R</I>)-α-(4-叔丁基苄基)-Pro-OH as an Impurity". Environ. Sci. Technol., 2012, 337, 5338-5345.
3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of (2R)-1-tert-butoxycarbonyl-2-(4-tert-butylbenzyl)proline (2R)-1-tert-butoxycarbonyl-2-[(4-tert-butylphenyl)methyl]pyrrolidine-2-carboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinecarboxylic acid (2R)-2-[(4-tert-butylphenyl)methyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 957310-66-6 Boc-(R)-alpha-(4-tert-butylphenyl)-proline Using HRMS and NMR". Talanta, 2021, 1659, (2), 5461-5482.

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