(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU) CAS 95740-26-4

5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione 95740-26-4

纯度 97%+现货药物标准品
CAS 号95740-26-4
分子式C11H11FN2O5
分子量270.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU) 5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione 95740-26-4 CAS 95740-26-4 结构式 Chemical Structure

产品介绍 Description

(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU)（5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione 95740-26-4，CAS 号 95740-26-4）是 CATO 佳途自主生产的药物标准品，分子式 C11H11FN2O5，分子量 270.21。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C11H11FN2O5 的(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU)（5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1-(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-ylpyrimidine-2,4-dione 95740-26-4），其CAS登记号是 95740-26-4，分子量为 270.21 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代的影响，(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU)表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）。

应用场景：(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU)（5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1- (2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl pyrimidine-2,4-dione 95740-26-4，CAS 95740-26-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以(

理化性质 Physical & Chemical Properties

中文名称(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU)
分子式C11H11FN2O5
分子量270.21 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. 发明人徐明华，张德明，周伟. "一种(2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU)的合成方法" [P]. 中国发明专利, 专利号 CN 115569127 A, 授权公告日 2015-10-05.
  2. Stevens L M, Yamamoto T, Williams B T. "Method for the Synthesis of 5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione 95740-26-4" [P]. US Patent, US 11829444 B2, 2018-12-04.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of (2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU) in Pharmaceutical Formulations". J. Agric. Food Chem., 2018, 389, 1085-1100.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU) as an Impurity". J. Chromatogr. A, 2023, 1864, 6934-6956.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 5-Ethynyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione 95740-26-4 Using HRMS and NMR". Sci. Total Environ., 2011, 1651, (10), 8232-8252.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate (2′<I>S</I>)-2′-脱氧-2′-氟-5-乙炔基尿苷 (F-ara-EdU) Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2013, 2114, (4), 4757-4767.

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