4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde CAS 958230-19-8

1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo[2,3-b]pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo[2.2.1]heptane

纯度 97%+现货药物标准品
CAS 号958230-19-8
分子式C8H13ClN2O
分子量188.65 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo[2,3-b]pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo[2.2.1]heptane CAS 958230-19-8 结构式 Chemical Structure

产品介绍 Description

4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde（1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo[2,3-b]pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo[2.2.1]heptane，CAS 号 958230-19-8）是 CATO 佳途自主生产的药物标准品，分子式 C8H13ClN2O，分子量 188.65。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

4-Chloro-1H-pyrrolo2,3-bpyridine-5-carbaldehyde的产生途径与其化学式中酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 4-Chloro-1H-pyrrolo2,3-bpyridine-5-carbaldehyde（1h-pyrrolo2,3-bpyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo2,3-bpyridine-5-carbaldehyde 4-chloro-1h-pyrrolo2,3-bpyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo2,3-bpyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo2,3-bpyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo2

应用场景：4-Chloro-1H-pyrrolo 2,3-b pyridine-5-carbaldehyde（1h-pyrrolo 2,3-b pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo 2,3-b pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo 2,3-b pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo 2,3-b pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-

理化性质 Physical & Chemical Properties

中文名称4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde
分子式C8H13ClN2O
分子量188.65 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1987年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人韩伟，胡光，王建平. "一种4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde的合成方法" [P]. 中国发明专利, 专利号 CN 112769836 A, 授权公告日 2023-03-25.
  2. 发明人钱学锋，陈志强，徐明华. "Method for the Synthesis of 1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo[2,3-b]pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo[2.2.1]heptane" [P]. 中国发明专利, 专利号 CN 108772657 B, 授权公告日 2023-10-18.
  3. Hughes D C, Kumar R, Patel M V. "A Process for Preparing High-Purity 1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro- 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carbaldehyde 4-chloro-1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-5-formyl-1h-pyrrolo[2,3-b]pyridine 4-chloro-7-azaindole-5-carboxaldehyde 4-chloro1h-pyrrolo[2,3-b]pyridine-5-carboxaldehyde 958230-19-8 anti-N-Cbz-7-hydroxy-2-azabicyclo[2.2.1]heptane" [P]. US Patent, US 10990530 B2, 2018-12-05.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde in Pharmaceutical Formulations". J. Agric. Food Chem., 2022, 1806, 8747-8759.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde as an Impurity". Molecules, 2024, 1560, 3180-3190.

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