5-氨基间苯二甲酸二甲酯 CAS 99-27-4
Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimethyl-5-aminoisophthalate 5-amino-iso-phthalic acid dimethyl ester dimethyl 5-amino-isophthalate 5-amino isophthalic acid, dimethyl ester 5-amino-dimethyl isophthalate 99-27-4
| CAS 号 | 99-27-4 |
| 分子式 | C10H17NO4 |
| 分子量 | 215.25 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
5-氨基间苯二甲酸二甲酯（英文名 Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimethyl-5-aminoisophthalate 5-amino-iso-phthalic acid dimethyl ester dimethyl 5-amino-isophthalate 5-amino isophthalic acid, dimethyl ester 5-amino-dimethyl isophthalate 99-27-4，CAS 99-27-4）属于药物标准品。分子式 C10H17NO4，分子量 215.25。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 5-氨基间苯二甲酸二甲酯（Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimethyl-5-aminoisophthalate 5-amino-iso-phthalic acid dimethyl ester dimethyl 5-amino-isophthalate 5-amino isophthalic acid, dimethyl ester
应用场景：5-氨基间苯二甲酸二甲酯（Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimet
理化性质 Physical & Chemical Properties
| 中文名称 | 5-氨基间苯二甲酸二甲酯 |
| 分子式 | C10H17NO4 |
| 分子量 | 215.25 g/mol |
| 外观形态 | 白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人何建平，陈志强，杨光. "一种5-氨基间苯二甲酸二甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 111592005 B, 授权公告日 2017-03-01.
- 发明人赵玉洁，黄志刚，郑宇鹏. "Method for the Synthesis of Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimethyl-5-aminoisophthalate 5-amino-iso-phthalic acid dimethyl ester dimethyl 5-amino-isophthalate 5-amino isophthalic acid, dimethyl ester 5-amino-dimethyl isophthalate 99-27-4" [P]. 中国发明专利, 专利号 CN 116100352 B, 授权公告日 2017-10-18.
- Davis P L, Johnson M A, Hughes D C. "A Process for Preparing High-Purity Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimethyl-5-aminoisophthalate 5-amino-iso-phthalic acid dimethyl ester dimethyl 5-amino-isophthalate 5-amino isophthalic acid, dimethyl ester 5-amino-dimethyl isophthalate 99-27-4" [P]. US Patent, US 10413001 B2, 2020-07-21.
参考文献 Literature
- O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 5-氨基间苯二甲酸二甲酯 in Pharmaceutical Formulations". Molecules, 2021, 811, 1530-1550.
- Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-氨基间苯二甲酸二甲酯 as an Impurity". J. Pharm. Biomed. Anal., 2011, 1766, 6535-6542.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of Dimethyl 5-aminoisophthalate Dimethyl 5-aminobenzene-1,3-dicarboxylate 1,3-benzenedicarboxylic acid, 5-amino-, dimethyl ester 5-amino-isophthalic acid dimethyl ester 5-aminoisophthalic acid dimethyl ester 5-amino-dimethyl iso-phthalate 1,3-dimethyl 5-aminobenzene-1,3-dicarboxylate dimethyl-5-aminoisophthalate 5-amino-iso-phthalic acid dimethyl ester dimethyl 5-amino-isophthalate 5-amino isophthalic acid, dimethyl ester 5-amino-dimethyl isophthalate 99-27-4 Using HRMS and NMR". J. Chromatogr. A, 2015, 2321, 4858-4888.
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