tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate CAS 1005556-39-7

tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号1005556-39-7
分子式C14H21BrN4O3
分子量373.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate CAS 1005556-39-7 结构式 Chemical Structure

产品介绍 Description

tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate（tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 1005556-39-7。分子式 C14H21BrN4O3，分子量 373.25。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，tert-butyl 4-(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonylpiperazine-1-carboxylate的分子量为373.25 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1005556-39-7 对应的化合物tert-butyl 4-(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonylpiperazine-1-carboxylate（英文标识 tert-butyl 4-(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonylpiperazine-1-carboxylate），化学式 C14H21BrN4O3，相对分子质量 373.25。 依据分子式为 C14H21BrN4O3 的tert-butyl 4-(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonylpiperazine-1-carboxylate结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含

应用场景：从实际应用出发，tert-butyl 4- (4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl piperazine-1-carboxylate（CAS 1005556-39-7）在化学分析中作为关键的基准对照物质。 推荐以tert-butyl 4- (4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl piperazine-1-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥

理化性质 Physical & Chemical Properties

中文名称tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate
分子式C14H21BrN4O3
分子量373.25 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量Br取代
含氮原子数4

相关专利 Related Patents

  1. Klinger H, Stevens L M, Schröder R. "一种tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate的合成方法" [P]. US Patent, US 10122868 B2, 2025-01-20.
  2. 发明人胡光，周伟，黄志刚. "Method for the Synthesis of tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 112507683 A, 授权公告日 2021-06-11.
  3. Stevens L M, Brown S R, Fischer A B. "A Process for Preparing High-Purity tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate" [P]. US Patent, US 10217903 B2, 2023-01-20.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate in Pharmaceutical Formulations". Chromatographia, 2023, 1049, 3916-3937.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate as an Impurity". Rapid Commun. Mass Spectrom., 2010, 1342, (12), 3708-3723.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2023, 149, (12), 6091-6119.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate tert-butyl 4-[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]piperazine-1-carboxylate Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2017, 198, (5), 9201-9210.

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