{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid CAS 1005592-03-9

{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid

纯度 97%+现货药物标准品
CAS 号1005592-03-9
分子式C14H19N5O3S
分子量337.40 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid CAS 1005592-03-9 结构式 Chemical Structure

产品介绍 Description

{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid（{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid，CAS 号 1005592-03-9）是 CATO 佳途自主生产的药物标准品，分子式 C14H19N5O3S，分子量 337.40。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

{5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio}acetic acid（C14H19N5O3S）含有含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。 {5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio}acetic acid（{5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio}acetic acid），CAS注册编号 1005592-03-9，化学分子式为 C14H19N5O3S，分子量 337.40 g/mo

应用场景：{ 5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl thio}acetic acid（{ 5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl thio}acetic acid，CAS 1005592-03-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以{ 5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylm

理化性质 Physical & Chemical Properties

中文名称{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid
分子式C14H19N5O3S
分子量337.40 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数5
含硫原子数1

相关专利 Related Patents

  1. Sørensen M, Johansson L, Mueller T C. "一种{[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid的合成方法" [P]. European Patent, EP 3658595 A1, 2021-09-26.
  2. 发明人唐晓军，张德明，沈红梅. "Method for the Synthesis of {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid" [P]. 中国发明专利, 专利号 CN 114757557 A, 授权公告日 2022-07-21.
  3. Sørensen M, Kowalski A, Lefèvre J P. "A Process for Preparing High-Purity {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid" [P]. European Patent, EP 3228304 A1, 2022-12-23.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2016, 2134, (5), 9484-9491.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid as an Impurity". Molecules, 2017, 2387, (3), 1557-1560.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid Using HRMS and NMR". Chemosphere, 2013, 644, (4), 5504-5509.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate {[5-(1-ethyl-1H-pyrazol-3-yl)-4-(tetrahydrofuran-2-ylmethyl)-4H-1,2,4-triazol-3-yl]thio}acetic acid Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2011, 1454, 5276-5285.

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