methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate CAS 1011396-58-9

methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

纯度 97%+现货药物标准品
CAS 号1011396-58-9
分子式C24H20FN3O2
分子量401.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate CAS 1011396-58-9 结构式 Chemical Structure

产品介绍 Description

methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate（methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate，CAS 号 1011396-58-9）是 CATO 佳途自主生产的药物标准品，分子式 C24H20FN3O2，分子量 401.43。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxylate的分子量为401.43 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C24H20FN3O2 的methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxylate（methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxylate），其CAS登记号是 1011396-58-9，分子量为 401.43 g/mol。 methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyri

应用场景：从实际应用出发，methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo 3,4-b pyridine-4-carboxylate（CAS 1011396-58-9）在化学分析中作为关键的基准对照物质。 推荐以methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo 3,4-b pyridine-4-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根

理化性质 Physical & Chemical Properties

中文名称methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
分子式C24H20FN3O2
分子量401.43 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）16.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人孙丽萍，朱建伟，林芳. "一种methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 115685309 A, 授权公告日 2023-08-16.
  2. 发明人郭海燕，黄志刚，沈红梅. "Method for the Synthesis of methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate" [P]. 中国发明专利, 专利号 CN 112451407 B, 授权公告日 2020-09-13.
  3. 发明人孙丽萍，郭海燕，朱建伟. "A Process for Preparing High-Purity methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate" [P]. 中国发明专利, 专利号 CN 113212466 B, 授权公告日 2024-12-22.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate in Pharmaceutical Formulations". Anal. Methods, 2014, 1421, (11), 557-570.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate as an Impurity". Phytochemistry, 2022, 1690, (4), 5501-5511.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate Using HRMS and NMR". Talanta, 2012, 2272, (2), 755-764.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2012, 2142, 4303-4318.

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